In vivo evaluation of protective effect of Sargassum fusiforme on cisplatin induced hepato - renal toxicity

Abstract

Hepato and Nephro toxicity is a known factor in cisplatin treated cancer patients. The present study is to investigate the chemical constituents of ethanolic extract of Sargassum fusiforme and the treatment efficacy of S. fusiforme against cisplatin induced hepato-nephro toxicity. Chemical components like 1, 19-Eicosadiene, Palmitic acid and 11-Dodecen-1-ol Trifluoroacetate were explored from ethanol extract of S. fusiforme by using a gas chromatograph-mass spectrograph (GC-MS). Cisplatin (single dose −5 mg/kg of body weight) was used to induce toxicity to rats by intraperitoneal injection. Seaweed ethanol extract of S. fusiforme at the different doses of 250, 350 and 450 mg/kg of b.w were orally administered to rats. Liver functioning enzymes like AST, ALP, ALT, Bilirubin, Total cholesterol and triglyceride levels were elevated in cisplatin administered rats when compared with control and whereas S. fusiforme treated rats showed that these enzyme levels were decreased when compared with cisplatin. Expression of kidney markers like serum creatinine, uric acid, urea, calcium, potassium, sodium, phosphorous were significantly increased with normalization of histological architecture in S. fusiforme treated rats when compared with cisplatin induced rats. The present study confirmed that the treatment with ethanol extract of S. fusiforme can be restoring the enzyme levels and architecture of hepato and nephro tissue damage induced by cisplatin. © 2021 Elsevier Ltd