Ratiometric fluorescent detection of lead ions in aquatic environment and living cells using a fluorescent peptide-based probe
DC Field | Value | Language |
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dc.contributor.author | Mehta, P.K. | - |
dc.contributor.author | Jeon, J. | - |
dc.contributor.author | Ryu, K. | - |
dc.contributor.author | Park, S.-H. | - |
dc.contributor.author | Lee, K.-H. | - |
dc.date.accessioned | 2022-02-17T04:41:57Z | - |
dc.date.available | 2022-02-17T04:41:57Z | - |
dc.date.created | 2022-02-17 | - |
dc.date.issued | 2022-04-05 | - |
dc.identifier.issn | 0304-3894 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hongik/handle/2020.sw.hongik/25307 | - |
dc.description.abstract | Ratiometric fluorescent detection using dual emission bands is highly necessary to quantify Pb(II) in aquatic environment and live cells. We synthesized a ratiometric fluorescent peptidyl probe (1) by conjugation of a peptide receptor for Pb(II) with an excimer-forming benzothiazolylcyanovinylene fluorophore. The peptidyl probe dissolved well in aqueous solution and displayed an emission band at 538 nm (λex = 460 nm). Upon addition of Pb(II) (0–20 μM), the emission maximum shifted from 538 nm to 575 nm and the emission intensity ratio (I575 /I538) increased significantly from 0.40 to 2.26. 1 exhibited a selective ratiometric response to Pb(II) over other metal ions. 1 with a low detection limit (1.2 ppb) of Pb(II) detected nanomolar concentrations (0–500 nM) of Pb(II) ions in groundwater and tap water. The cell-permeable probe detected intracellular Pb(II) by ratiometric fluorescent images. The binding mode study using NMR, IR and CD spectroscopy, and TEM revealed that the probe formed a 1:1 complex with Pb(II) and then formed red-emissive nanoparticles and fibrils. The probe exhibited desirable detection properties such as ratiometric detection, high solubility in water, visible light excitation, high selectivity and sensitivity for Pb(II), cell-permeability, and rapid response (< 6 min). © 2022 Elsevier B.V. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | Elsevier B.V. | - |
dc.title | Ratiometric fluorescent detection of lead ions in aquatic environment and living cells using a fluorescent peptide-based probe | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Park, S.-H. | - |
dc.identifier.doi | 10.1016/j.jhazmat.2021.128161 | - |
dc.identifier.scopusid | 2-s2.0-85122677034 | - |
dc.identifier.wosid | 000752478800005 | - |
dc.identifier.bibliographicCitation | Journal of Hazardous Materials, v.427 | - |
dc.relation.isPartOf | Journal of Hazardous Materials | - |
dc.citation.title | Journal of Hazardous Materials | - |
dc.citation.volume | 427 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Engineering | - |
dc.relation.journalResearchArea | Environmental Sciences & Ecology | - |
dc.relation.journalWebOfScienceCategory | Engineering, Environmental | - |
dc.relation.journalWebOfScienceCategory | Environmental Sciences | - |
dc.subject.keywordPlus | AQUEOUS-SOLUTIONS | - |
dc.subject.keywordPlus | METAL-IONS | - |
dc.subject.keywordPlus | SENSOR | - |
dc.subject.keywordPlus | EMISSION | - |
dc.subject.keywordPlus | PB2+ | - |
dc.subject.keywordPlus | PB(II) | - |
dc.subject.keywordPlus | ACID | - |
dc.subject.keywordAuthor | Fluorescent | - |
dc.subject.keywordAuthor | Lead | - |
dc.subject.keywordAuthor | Pb(II) | - |
dc.subject.keywordAuthor | Probe | - |
dc.subject.keywordAuthor | Sensor | - |
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