Hydrophilized poly(lactide-co-glycolide) nanospheres with poly(ethylene oxide)-poly(propylene oxide)-poly(ethylene oxide) triblock copolymer
DC Field | Value | Language |
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dc.contributor.author | Kim, BK | - |
dc.contributor.author | Kim, D | - |
dc.contributor.author | Cho, SH | - |
dc.contributor.author | Yuk, SH | - |
dc.date.accessioned | 2022-02-18T07:41:04Z | - |
dc.date.available | 2022-02-18T07:41:04Z | - |
dc.date.created | 2022-02-18 | - |
dc.date.issued | 2004-11 | - |
dc.identifier.issn | 0265-2048 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hongik/handle/2020.sw.hongik/25731 | - |
dc.description.abstract | A novel method for preparing the PLGA nanospheres with hydrophilic surface has been designed and characterized. Because of good solubility of tetraglycol in water, PLGA (poly(lactide-co-glycolide)) nanospheres were formed by spraying the PLGA/tetraglycol solution into water. The size of PLGA nanospheres was manipulated by changing the concentration of PLGA/tetraglycol solution. Based on the hydrophobic interaction between PLGA and poly(propylene oxide) domain of F-127 (one of Pluronics, poly(ethylene oxide)-poly(propylene oxide)-poly(ethylene oxide) triblock copolymer, F-127-coated PLGA nanospheres was prepared to enhance the stability of PLGA nanospheres in the aqueous media. For the application as a drug delivery vehicle, it was characterized by measuring the loading amount, the encapsulation efficiency and the release pattern of drug. Paclitaxel used as a potent anti-cancer drug was selected as a model drug. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | TAYLOR & FRANCIS LTD | - |
dc.subject | MICROSPHERES | - |
dc.subject | MICELLES | - |
dc.subject | DELIVERY | - |
dc.subject | RELEASE | - |
dc.title | Hydrophilized poly(lactide-co-glycolide) nanospheres with poly(ethylene oxide)-poly(propylene oxide)-poly(ethylene oxide) triblock copolymer | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, D | - |
dc.identifier.doi | 10.1080/02652040400000520 | - |
dc.identifier.scopusid | 2-s2.0-11944265984 | - |
dc.identifier.wosid | 000226205900001 | - |
dc.identifier.bibliographicCitation | JOURNAL OF MICROENCAPSULATION, v.21, no.7, pp.697 - 707 | - |
dc.relation.isPartOf | JOURNAL OF MICROENCAPSULATION | - |
dc.citation.title | JOURNAL OF MICROENCAPSULATION | - |
dc.citation.volume | 21 | - |
dc.citation.number | 7 | - |
dc.citation.startPage | 697 | - |
dc.citation.endPage | 707 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalResearchArea | Engineering | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Applied | - |
dc.relation.journalWebOfScienceCategory | Engineering, Chemical | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.subject.keywordPlus | MICROSPHERES | - |
dc.subject.keywordPlus | MICELLES | - |
dc.subject.keywordPlus | DELIVERY | - |
dc.subject.keywordPlus | RELEASE | - |
dc.subject.keywordAuthor | hydrophilized poly(lactide-co-glycolide) nanospheres | - |
dc.subject.keywordAuthor | pluronics | - |
dc.subject.keywordAuthor | tetraglycol | - |
dc.subject.keywordAuthor | paclitaxel | - |
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