Ratiometric red-emission fluorescence detection of Al3+ in pure aqueous solution and live cells by a fluorescent peptidyl probe using aggregation-induced emission
- Authors
- Neupane, Lok Nath; Mehta, Pramod Kumar; Oh, Semin; Park, See-Hyoung; Lee, Keun-Hyeung
- Issue Date
- 7-Nov-2018
- Publisher
- ROYAL SOC CHEMISTRY
- Citation
- ANALYST, v.143, no.21, pp.5285 - 5294
- Journal Title
- ANALYST
- Volume
- 143
- Number
- 21
- Start Page
- 5285
- End Page
- 5294
- URI
- https://scholarworks.bwise.kr/hongik/handle/2020.sw.hongik/2973
- DOI
- 10.1039/c8an01221k
- ISSN
- 0003-2654
- Abstract
- The development of a fluorescence method for the selective ratiometric detection of Al3+ ions in pure aqueous solutions and live cells is still a significant challenge. In the present study, we synthesized a new type of fluorescent probe using an Al3+-triggered self-assembly based on the dipeptide receptor and an aggregation-induced emission fluorophore. The fluorescent probe (1) bearing cyanostilbene with excitation by visible light detected Al3+ ions sensitively in pure aqueous buffered solution by ratiometric red-emission at 600 nm. 1 provided a highly selective ratiometric detection of Al3+ among 16 metal ions in aqueous solution. 1 exhibited sensitive ratiometric response to Al3+ in aqueous buffered solutions at pH ranging from 5 to 7.4. The detection limit (145 nM, R-2 = 0.999) for Al3+ ions in pure aqueous solution was much lower than the maximum allowable level of Al3+ in drinking water demanded by the Environmental Protection Agency (EPA). The probe provided an efficient approach to detect low concentrations of Al3+ in ground water, tap water, and live cells by ratiometric red-emissions at 600 nm. The binding study using dynamic light scattering, NMR, IR, and TEM revealed that the complex between 1 and Al3+ self-assembled to form nanoparticles, resulting in the enhancement of the emission at 600 nm and a concomitant decrease in the emission at 535 nm.
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Collections - College of Science and Technology > Department of Biological and Chemical Engineering > 1. Journal Articles
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