Enhanced production of glutaric acid by biocatalyst-recycled bioconversion process integrated with in situ product recovery by adsorption
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Cha, Haeng-Geun | - |
dc.contributor.author | Kim, Hee Taek | - |
dc.contributor.author | Park, See-Hyoung | - |
dc.contributor.author | Kong, Youjung | - |
dc.contributor.author | Yi, Byongson | - |
dc.contributor.author | Wang, Jimin | - |
dc.contributor.author | Song, Eunchae | - |
dc.contributor.author | Joo, Jeong Chan | - |
dc.contributor.author | Yang, Yung-Hun | - |
dc.contributor.author | Ahn, Jung-Oh | - |
dc.contributor.author | Park, Kyungmoon | - |
dc.date.accessioned | 2023-09-27T07:40:16Z | - |
dc.date.available | 2023-09-27T07:40:16Z | - |
dc.date.issued | 2023-12 | - |
dc.identifier.issn | 0141-0229 | - |
dc.identifier.issn | 1879-0909 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hongik/handle/2020.sw.hongik/31699 | - |
dc.description.abstract | Product inhibition caused by organic acids is a serious issue in establishing economical biochemical production systems. Herein, for enhanced production of glutaric acid by overcoming product inhibition triggered by glutaric acid, a whole-cell bioconversion system equipped with biocatalyst recycling process and in situ product recovery by adsorption was developed successfully. From the whole-cell bioconversion reaction, we found that both dissociated and undissociated forms of glutaric acid acted as an inhibitor in the whole-cell bioconversion reaction, wherein bioconversion was hindered beyond 200 mM glutaric acid regardless of reaction pH. Therefore, as the promising solution for the inhibition issue by glutaric acid, the biocatalyst-recycled bioconversion process integrated with in situ product recovery by adsorption was introduced in the whole-cell bioconversion. As a result, 592 mM glutaric acid was produced from 1000 mM 5-aminovaleric acid with 59.2% conversion. We believe that our system will be a promising candidate for economically producing organic acids with high titer. © 2023 Elsevier Inc. | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | Elsevier Inc. | - |
dc.title | Enhanced production of glutaric acid by biocatalyst-recycled bioconversion process integrated with in situ product recovery by adsorption | - |
dc.type | Article | - |
dc.publisher.location | 미국 | - |
dc.identifier.doi | 10.1016/j.enzmictec.2023.110307 | - |
dc.identifier.scopusid | 2-s2.0-85171556046 | - |
dc.identifier.wosid | 001071576400001 | - |
dc.identifier.bibliographicCitation | Enzyme and Microbial Technology, v.171 | - |
dc.citation.title | Enzyme and Microbial Technology | - |
dc.citation.volume | 171 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biotechnology & Applied Microbiology | - |
dc.relation.journalWebOfScienceCategory | Biotechnology & Applied Microbiology | - |
dc.subject.keywordAuthor | Glutaric acid | - |
dc.subject.keywordAuthor | Glutaric acid adsorption | - |
dc.subject.keywordAuthor | in situ product recovery | - |
dc.subject.keywordAuthor | Product inhibition | - |
dc.subject.keywordAuthor | Whole-cell bioconversion | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
94, Wausan-ro, Mapo-gu, Seoul, 04066, Korea02-320-1314
COPYRIGHT 2020 HONGIK UNIVERSITY. ALL RIGHTS RESERVED.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.