High-fidelity mesoscale in-vivo diffusion MRI through gSlider-BUDA and circular EPI with S-LORAKS reconstructionopen access
- Authors
- Liao, C.; Yarach, U.; Cao, X.; Iyer, S.S.; Wang, N.; Kim, T.H.; Tian, Q.; Bilgic, B.; Kerr, A.B.; Setsompop, K.
- Issue Date
- 15-Jul-2023
- Publisher
- Academic Press Inc.
- Keywords
- Diffusion MRI; Distortion correction; Echo-planar imaging
- Citation
- NeuroImage, v.275
- Journal Title
- NeuroImage
- Volume
- 275
- URI
- https://scholarworks.bwise.kr/hongik/handle/2020.sw.hongik/32683
- DOI
- 10.1016/j.neuroimage.2023.120168
- ISSN
- 1053-8119
1095-9572
- Abstract
- Purpose: To develop a high-fidelity diffusion MRI acquisition and reconstruction framework with reduced echo-train-length for less T2* image blurring compared to typical highly accelerated echo-planar imaging (EPI) acquisitions at sub-millimeter isotropic resolution. Methods: We first proposed a circular-EPI trajectory with partial Fourier sampling on both the readout and phase-encoding directions to minimize the echo-train-length and echo time. We then utilized this trajectory in an interleaved two-shot EPI acquisition with reversed phase-encoding polarity, to aid in the correction of off-resonance-induced image distortions and provide complementary k-space coverage in the missing partial Fourier regions. Using model-based reconstruction with structured low-rank constraint and smooth phase prior, we corrected the shot-to-shot phase variations across the two shots and recover the missing k-space data. Finally, we combined the proposed acquisition/reconstruction framework with an SNR-efficient RF-encoded simultaneous multi-slab technique, termed gSlider, to achieve high-fidelity 720 µm and 500 µm isotropic resolution in-vivo diffusion MRI. Results: Both simulation and in-vivo results demonstrate the effectiveness of the proposed acquisition and reconstruction framework to provide distortion-corrected diffusion imaging at the mesoscale with markedly reduced T2*-blurring. The in-vivo results of 720 µm and 500 µm datasets show high-fidelity diffusion images with reduced image blurring and echo time using the proposed approaches. Conclusions: The proposed method provides high-quality distortion-corrected diffusion-weighted images with ∼40% reduction in the echo-train-length and T2* blurring at 500µm-isotropic-resolution compared to standard multi-shot EPI. © 2023 The Author(s)
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