Microfluidic gut-axis-on-a-chip models for pharmacokinetic-based disease models
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Raehyun | - |
dc.contributor.author | Sung, Jong Hwan | - |
dc.date.accessioned | 2024-07-16T07:30:20Z | - |
dc.date.available | 2024-07-16T07:30:20Z | - |
dc.date.issued | 2024-05 | - |
dc.identifier.issn | 1932-1058 | - |
dc.identifier.issn | 1932-1058 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hongik/handle/2020.sw.hongik/33362 | - |
dc.description.abstract | The low success rate of new drugs transitioning from animal testing to human clinical trials necessitates the development of more accurate and representative in vitro models. Recent advances in multi-organ-on-a-chip technology offer promising avenues for studying complex organ-organ interactions. Gut-liver-on-a-chip systems hold particular promise for mimicking the intricate interplay between the gut and liver, which play crucial roles in nutrient absorption, drug metabolism, detoxification, and immune response. Here, we discuss the key components of the gut-liver axis, including the gut epithelium, liver cells, gut microbiota, and their roles in the organ functions. We then explore the potential of gut-liver-on-a-chip models to replicate the intricate interactions between the two organs for pharmacokinetic studies and their expansion to more complicated multi-organ models. Finally, we provide perspectives and future directions for developing more physiologically relevant gut-liver-axis models for more efficient drug development, studying liver diseases, and personalizing treatment strategies. | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | AIP Publishing | - |
dc.title | Microfluidic gut-axis-on-a-chip models for pharmacokinetic-based disease models | - |
dc.type | Article | - |
dc.publisher.location | 미국 | - |
dc.identifier.doi | 10.1063/5.0206271 | - |
dc.identifier.scopusid | 2-s2.0-85197361245 | - |
dc.identifier.wosid | 001257930000002 | - |
dc.identifier.bibliographicCitation | BIOMICROFLUIDICS, v.18, no.3 | - |
dc.citation.title | BIOMICROFLUIDICS | - |
dc.citation.volume | 18 | - |
dc.citation.number | 3 | - |
dc.type.docType | Review | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Biophysics | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.relation.journalResearchArea | Physics | - |
dc.relation.journalWebOfScienceCategory | Biochemical Research Methods | - |
dc.relation.journalWebOfScienceCategory | Biophysics | - |
dc.relation.journalWebOfScienceCategory | Nanoscience & Nanotechnology | - |
dc.relation.journalWebOfScienceCategory | Physics, Fluids & Plasmas | - |
dc.subject.keywordPlus | IN-VITRO MODELS | - |
dc.subject.keywordPlus | MICROPHYSIOLOGICAL SYSTEMS | - |
dc.subject.keywordPlus | MICROBIOTA INTERACTIONS | - |
dc.subject.keywordPlus | INTESTINAL MONOLAYERS | - |
dc.subject.keywordPlus | LIVER-DISEASE | - |
dc.subject.keywordPlus | CELL-LINES | - |
dc.subject.keywordPlus | METABOLISM | - |
dc.subject.keywordPlus | INFLAMMATION | - |
dc.subject.keywordPlus | TOXICITY | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
94, Wausan-ro, Mapo-gu, Seoul, 04066, Korea02-320-1314
COPYRIGHT 2020 HONGIK UNIVERSITY. ALL RIGHTS RESERVED.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.