Detailed Information

Cited 58 time in webofscience Cited 65 time in scopus
Metadata Downloads

Microfluidic gut-on-a-chip with three-dimensional villi structure

Full metadata record
DC Field Value Language
dc.contributor.authorShim, Kyu-Young-
dc.contributor.authorLee, Dongwook-
dc.contributor.authorHan, Jeonghun-
dc.contributor.authorNam-Trung Nguyen-
dc.contributor.authorPark, Sungsu-
dc.contributor.authorSung, Jong Hwan-
dc.date.available2020-07-10T05:02:27Z-
dc.date.created2020-07-06-
dc.date.issued2017-06-
dc.identifier.issn1387-2176-
dc.identifier.urihttps://scholarworks.bwise.kr/hongik/handle/2020.sw.hongik/5698-
dc.description.abstractCurrent in vitro gut models lack physiological relevance, and various approaches have been taken to improve current cell culture models. For example, mimicking the three-dimensional (3D) tissue structure or fluidic environment has been shown to improve the physiological function of gut cells. Here, we incorporated a collagen scaffold that mimics the human intestinal villi into a microfluidic device, thus providing cells with both 3D tissue structure and fluidic shear. We hypothesized that the combined effect of 3D structure and fluidic shear may provide cells with adequate stimulus to induce further differentiation and improve physiological relevance. The physiological function of our '3D gut chip' was assessed by measuring the absorptive permeability of the gut epithelium and activity of representative enzymes, as well as morphological evaluation. Our results suggest that the combination of fluidic stimulus and 3D structure induces further improvement in gut functions. Our work provides insight into the effect of different tissue environment on gut cells.-
dc.language영어-
dc.language.isoen-
dc.publisherSPRINGER-
dc.subjectP-GLYCOPROTEIN SUBSTRATE-
dc.subjectIN-VITRO-
dc.subjectINTESTINAL SCAFFOLDS-
dc.subjectCOCULTURE MODEL-
dc.subjectCACO-2-
dc.subjectCELLS-
dc.subjectTRANSPORT-
dc.subjectMICROENVIRONMENT-
dc.subjectDIFFERENTIATION-
dc.subjectRHODAMINE-123-
dc.titleMicrofluidic gut-on-a-chip with three-dimensional villi structure-
dc.typeArticle-
dc.contributor.affiliatedAuthorSung, Jong Hwan-
dc.identifier.doi10.1007/s10544-017-0179-y-
dc.identifier.scopusid2-s2.0-85018875955-
dc.identifier.wosid000400547000019-
dc.identifier.bibliographicCitationBIOMEDICAL MICRODEVICES, v.19, no.2-
dc.relation.isPartOfBIOMEDICAL MICRODEVICES-
dc.citation.titleBIOMEDICAL MICRODEVICES-
dc.citation.volume19-
dc.citation.number2-
dc.type.rimsART-
dc.type.docTypeArticle-
dc.description.journalClass1-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.relation.journalResearchAreaEngineering-
dc.relation.journalResearchAreaScience & Technology - Other Topics-
dc.relation.journalWebOfScienceCategoryEngineering, Biomedical-
dc.relation.journalWebOfScienceCategoryNanoscience & Nanotechnology-
dc.subject.keywordPlusP-GLYCOPROTEIN SUBSTRATE-
dc.subject.keywordPlusIN-VITRO-
dc.subject.keywordPlusINTESTINAL SCAFFOLDS-
dc.subject.keywordPlusCOCULTURE MODEL-
dc.subject.keywordPlusCACO-2-
dc.subject.keywordPlusCELLS-
dc.subject.keywordPlusTRANSPORT-
dc.subject.keywordPlusMICROENVIRONMENT-
dc.subject.keywordPlusDIFFERENTIATION-
dc.subject.keywordPlusRHODAMINE-123-
dc.subject.keywordAuthorGut-on-a-chip-
dc.subject.keywordAuthorOrgan-on-a-chip-
dc.subject.keywordAuthorMicrofluidic-
dc.subject.keywordAuthor3D cell culture-
Files in This Item
There are no files associated with this item.
Appears in
Collections
College of Engineering > Chemical Engineering Major > 1. Journal Articles

qrcode

Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.

Related Researcher

Researcher Sung, Jong Hwan photo

Sung, Jong Hwan
Engineering (Chemical Engineering)
Read more

Altmetrics

Total Views & Downloads

BROWSE