Microphysiological systems for recapitulating physiology and function of blood-brain barrier
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Seo, Suyeong | - |
dc.contributor.author | Kim, Hwieun | - |
dc.contributor.author | Sung, Jong Hwan | - |
dc.contributor.author | Choi, Nakwon | - |
dc.contributor.author | Lee, Kangwon | - |
dc.contributor.author | Kim, Hong Nam | - |
dc.date.available | 2020-07-10T02:30:53Z | - |
dc.date.created | 2020-07-06 | - |
dc.date.issued | 2020-02 | - |
dc.identifier.issn | 0142-9612 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hongik/handle/2020.sw.hongik/594 | - |
dc.description.abstract | Central nervous system (CNS) diseases are emerging as a major issue in an aging society. Although extensive research has focused on the development of CNS drugs, the limited transport of therapeutic agents across the blood-brain barrier (BBB) remains a major challenge. Conventional two-dimensional culture dishes do not recapitulate in vivo physiology and real-time observations of molecular transport are not possible in animal models. Recent advances in engineering techniques have enabled the generation of more physiologically relevant in vitro BBB models, and their applications have expanded from fundamental biological research to practical applications in the pharmaceutical industry. In this article, we provide an overview of recent advances in the development of in vitro BBB models, with a particular focus on the recapitulation of BBB function. The development of biomimetic BBB models is postulated to revolutionize not only fundamental biological studies but also drug screening. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER SCI LTD | - |
dc.subject | IN-VITRO MODELS | - |
dc.subject | TRANSENDOTHELIAL ELECTRICAL-RESISTANCE | - |
dc.subject | ASTROCYTE-ENDOTHELIAL INTERACTIONS | - |
dc.subject | BASEMENT-MEMBRANE PROTEINS | - |
dc.subject | TIGHT JUNCTION | - |
dc.subject | TRANSMEMBRANE PROTEINS | - |
dc.subject | EXTRACELLULAR-MATRIX | - |
dc.subject | ALZHEIMERS-DISEASE | - |
dc.subject | P-GLYCOPROTEIN | - |
dc.subject | REACTIVE ASTROCYTES | - |
dc.title | Microphysiological systems for recapitulating physiology and function of blood-brain barrier | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Sung, Jong Hwan | - |
dc.identifier.doi | 10.1016/j.biomaterials.2019.119732 | - |
dc.identifier.scopusid | 2-s2.0-85078722215 | - |
dc.identifier.wosid | 000514748200004 | - |
dc.identifier.bibliographicCitation | BIOMATERIALS, v.232 | - |
dc.relation.isPartOf | BIOMATERIALS | - |
dc.citation.title | BIOMATERIALS | - |
dc.citation.volume | 232 | - |
dc.type.rims | ART | - |
dc.type.docType | Review | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Engineering | - |
dc.relation.journalResearchArea | Materials Science | - |
dc.relation.journalWebOfScienceCategory | Engineering, Biomedical | - |
dc.relation.journalWebOfScienceCategory | Materials Science, Biomaterials | - |
dc.subject.keywordPlus | IN-VITRO MODELS | - |
dc.subject.keywordPlus | TRANSENDOTHELIAL ELECTRICAL-RESISTANCE | - |
dc.subject.keywordPlus | ASTROCYTE-ENDOTHELIAL INTERACTIONS | - |
dc.subject.keywordPlus | BASEMENT-MEMBRANE PROTEINS | - |
dc.subject.keywordPlus | TIGHT JUNCTION | - |
dc.subject.keywordPlus | TRANSMEMBRANE PROTEINS | - |
dc.subject.keywordPlus | EXTRACELLULAR-MATRIX | - |
dc.subject.keywordPlus | ALZHEIMERS-DISEASE | - |
dc.subject.keywordPlus | P-GLYCOPROTEIN | - |
dc.subject.keywordPlus | REACTIVE ASTROCYTES | - |
dc.subject.keywordAuthor | Blood brain barrier | - |
dc.subject.keywordAuthor | Neurovascular unit | - |
dc.subject.keywordAuthor | In vitro models | - |
dc.subject.keywordAuthor | Physiological relevance | - |
dc.subject.keywordAuthor | Vascular permeability | - |
dc.subject.keywordAuthor | Drug screening | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
94, Wausan-ro, Mapo-gu, Seoul, 04066, Korea02-320-1314
COPYRIGHT 2020 HONGIK UNIVERSITY. ALL RIGHTS RESERVED.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.