Afzelin positively regulates melanogenesis through the p38 MAPK pathway
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Jung, Eunsun | - |
dc.contributor.author | Kim, Jin Hee | - |
dc.contributor.author | Kim, Mi Ok | - |
dc.contributor.author | Jang, Sunghee | - |
dc.contributor.author | Kang, Mingyeong | - |
dc.contributor.author | Oh, Sae Woong | - |
dc.contributor.author | Nho, Youn Hwa | - |
dc.contributor.author | Kang, Seung Hyun | - |
dc.contributor.author | Kim, Min Hee | - |
dc.contributor.author | Park, See-Hyoung | - |
dc.contributor.author | Lee, Jongsung | - |
dc.date.available | 2020-07-10T06:00:57Z | - |
dc.date.created | 2020-07-06 | - |
dc.date.issued | 2016-07-25 | - |
dc.identifier.issn | 0009-2797 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hongik/handle/2020.sw.hongik/7561 | - |
dc.description.abstract | Melanogenesis refers to synthesis of the skin pigment melanin, which plays a critical role in the protection of skin against ultraviolet irradiation and oxidative stressors. We investigated the effects of afzelin on melanogenesis and its mechanisms of action in human epidermal melanocytes. In this study, we found that afzelin increased both melanin content and tyrosinase activity in a concentration-dependent manner. While the mRNA levels of microphthalmia-associated transcription factor (MITF), tyrosinase, and tyrosinase-related protein (TRP)-1 increased following afzelin treatment, the mRNA levels of TRP-2 were not affected by afzelin. Likewise, afzelin increased the protein levels of MITF, TRP-1, and tyrosinase but not TRP-2. Mechanistically, we found that afzelin regulated melanogenesis by upregulating MITF through phosphorylation of p38 mitogen-activated protein kinase (MAPK), independent of cyclic adenosine monophosphate (cAMP)-protein kinase A (PKA) signaling. Taken together, these findings indicate that the promotion of melanogenesis by afzelin occurs through increased MITF gene expression, which is mediated by activation of p38 MAPK, and suggest that afzelin may be useful as a protective agent against ultraviolet irradiation. (C) 2016 Elsevier Ireland Ltd. All rights reserved. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER IRELAND LTD | - |
dc.subject | TYROSINASE-RELATED PROTEIN-1 | - |
dc.subject | BROWN LOCUS PRODUCT | - |
dc.subject | TRANSCRIPTION FACTOR | - |
dc.subject | PHOSPHATIDYLINOSITOL-3-KINASE PATHWAY | - |
dc.subject | DOPACHROME TAUTOMERASE | - |
dc.subject | FUNCTIONAL-ANALYSIS | - |
dc.subject | MELANOMA-CELLS | - |
dc.subject | MELANOCYTES | - |
dc.subject | ACTIVATION | - |
dc.subject | PHEOMELANOGENESIS | - |
dc.title | Afzelin positively regulates melanogenesis through the p38 MAPK pathway | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Park, See-Hyoung | - |
dc.identifier.doi | 10.1016/j.cbi.2016.06.010 | - |
dc.identifier.scopusid | 2-s2.0-84973910995 | - |
dc.identifier.wosid | 000378764900018 | - |
dc.identifier.bibliographicCitation | CHEMICO-BIOLOGICAL INTERACTIONS, v.254, pp.167 - 172 | - |
dc.relation.isPartOf | CHEMICO-BIOLOGICAL INTERACTIONS | - |
dc.citation.title | CHEMICO-BIOLOGICAL INTERACTIONS | - |
dc.citation.volume | 254 | - |
dc.citation.startPage | 167 | - |
dc.citation.endPage | 172 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalResearchArea | Toxicology | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Toxicology | - |
dc.subject.keywordPlus | TYROSINASE-RELATED PROTEIN-1 | - |
dc.subject.keywordPlus | BROWN LOCUS PRODUCT | - |
dc.subject.keywordPlus | TRANSCRIPTION FACTOR | - |
dc.subject.keywordPlus | PHOSPHATIDYLINOSITOL-3-KINASE PATHWAY | - |
dc.subject.keywordPlus | DOPACHROME TAUTOMERASE | - |
dc.subject.keywordPlus | FUNCTIONAL-ANALYSIS | - |
dc.subject.keywordPlus | MELANOMA-CELLS | - |
dc.subject.keywordPlus | MELANOCYTES | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | PHEOMELANOGENESIS | - |
dc.subject.keywordAuthor | Afzelin | - |
dc.subject.keywordAuthor | Melanogenesis | - |
dc.subject.keywordAuthor | p38MAPK | - |
dc.subject.keywordAuthor | MITF | - |
dc.subject.keywordAuthor | TRP-1 | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
94, Wausan-ro, Mapo-gu, Seoul, 04066, Korea02-320-1314
COPYRIGHT 2020 HONGIK UNIVERSITY. ALL RIGHTS RESERVED.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.