Tumor-suppressive activity of 1,25-dihydroxyvitamin D3 against kidney cancer cells via up-regulation of FOXO3
DC Field | Value | Language |
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dc.contributor.author | Lee, Jongsung | - |
dc.contributor.author | Park, See-Hyoung | - |
dc.date.available | 2020-07-10T06:41:53Z | - |
dc.date.created | 2020-07-06 | - |
dc.date.issued | 2016 | - |
dc.identifier.issn | 0916-8451 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hongik/handle/2020.sw.hongik/8839 | - |
dc.description.abstract | 1,25-Dihydroxyvitamin D3 has been known to have the tumor-suppressive activity in various kinds of tumors. However, the exact effect and working mechanism of 1,25-dihydroxyvitamin D3 on the tumor-suppressive activity in human kidney cancer cells remains poorly understood. 1,25-Dihydroxyvitamin D3 has cytotoxicity to ACHN cells and inhibited ACHN cell proliferation compared to the vehicle control. 1,25-Dihydroxyvitamin D3 increased the expression of the cleaved PARP1, active Caspase3, Bax, and Bim but decreased the expression of Bcl2 in ACHN cells. Moreover, 1,25-dihydroxyvitamin D3 down-regulated the phosphorylated Akt and Erk which might lead to apoptosis through activation of FOXO3 in ACHN cells. Transfection of siRNA against FOXO3 attenuated the pro-apoptotic BimEL expression in ACHN cells treated with 1,25-dihydroxyvitamin D3. These results suggest that FOXO3 is involved in the apoptosis induced by 1,25-dihydroxyvitamin D3. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | TAYLOR & FRANCIS LTD | - |
dc.subject | VITAMIN-D-3 ANALOG EB1089 | - |
dc.subject | NCI-H929 MYELOMA CELLS | - |
dc.subject | TRANSCRIPTION FACTORS | - |
dc.subject | COLORECTAL-CANCER | - |
dc.subject | OVARIAN-CANCER | - |
dc.subject | RENAL-CANCER | - |
dc.subject | D-RECEPTOR | - |
dc.subject | IN-VITRO | - |
dc.subject | APOPTOSIS | - |
dc.subject | PROSTATE | - |
dc.title | Tumor-suppressive activity of 1,25-dihydroxyvitamin D3 against kidney cancer cells via up-regulation of FOXO3 | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Park, See-Hyoung | - |
dc.identifier.doi | 10.1080/09168451.2016.1184561 | - |
dc.identifier.scopusid | 2-s2.0-84986302327 | - |
dc.identifier.wosid | 000383046300012 | - |
dc.identifier.bibliographicCitation | BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, v.80, no.10, pp.1947 - 1953 | - |
dc.relation.isPartOf | BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY | - |
dc.citation.title | BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY | - |
dc.citation.volume | 80 | - |
dc.citation.number | 10 | - |
dc.citation.startPage | 1947 | - |
dc.citation.endPage | 1953 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Biotechnology & Applied Microbiology | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalResearchArea | Food Science & Technology | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Biotechnology & Applied Microbiology | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Applied | - |
dc.relation.journalWebOfScienceCategory | Food Science & Technology | - |
dc.subject.keywordPlus | VITAMIN-D-3 ANALOG EB1089 | - |
dc.subject.keywordPlus | NCI-H929 MYELOMA CELLS | - |
dc.subject.keywordPlus | TRANSCRIPTION FACTORS | - |
dc.subject.keywordPlus | COLORECTAL-CANCER | - |
dc.subject.keywordPlus | OVARIAN-CANCER | - |
dc.subject.keywordPlus | RENAL-CANCER | - |
dc.subject.keywordPlus | D-RECEPTOR | - |
dc.subject.keywordPlus | IN-VITRO | - |
dc.subject.keywordPlus | APOPTOSIS | - |
dc.subject.keywordPlus | PROSTATE | - |
dc.subject.keywordAuthor | tumor-suppressive | - |
dc.subject.keywordAuthor | 1 | - |
dc.subject.keywordAuthor | 25-dihydroxyvitamin D3 | - |
dc.subject.keywordAuthor | kidney | - |
dc.subject.keywordAuthor | cancer | - |
dc.subject.keywordAuthor | FOXO3 | - |
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