Protective effects of hepatocyte growth factor gene overexpression against hydrogen peroxide-induced apoptosis in mesenchymal stem cells
DC Field | Value | Language |
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dc.contributor.author | Choi, Yong Jun | - |
dc.contributor.author | Lee, Chang Min | - |
dc.contributor.author | Lee, Jeong Hyun | - |
dc.contributor.author | Park, See-Hyoung | - |
dc.contributor.author | Nam, Myeong Jin | - |
dc.date.available | 2020-07-10T02:38:09Z | - |
dc.date.created | 2020-07-06 | - |
dc.date.issued | 2019-11 | - |
dc.identifier.issn | 1520-4081 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hongik/handle/2020.sw.hongik/961 | - |
dc.description.abstract | Hepatocyte growth factor (HGF) has recently been reported to exhibit antioxidant and antiapoptotic effects. Therefore, we investigated the effect of overexpression of HGF gene in H2O2-treated mesenchymal stem cells (MSCs). HGF-overexpression increased the cell viability from 50% to 84%, decreased the population of apoptotic cells from 20% to 16%, and decreased the intracellular reactive oxygen species (ROS) levels from 127% to 100% in cells treated with H2O2. HGF suppression decreased the cell viability from 58% to 36%, increased the population of apoptotic cells from 23 to 81%, and increased the intracellular ROS levels from 181% to 240% in cells exposed to H2O2. HGF-overexpression also reduced the expression levels of proapoptotic proteins in MSCs treated with H2O2. Phosphorylation of extracellular signal-regulated kinases, c-Jun amino-terminal kinases, and p38, which was induced by H2O2, decreased in MSCs overexpressing the HGF gene. Taken together, our results suggest that HGF has a protective effect on H2O2-induced apoptosis in MSCs. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | WILEY | - |
dc.subject | NADPH OXIDASES | - |
dc.subject | CANCER | - |
dc.subject | ACTIVATION | - |
dc.subject | PATHWAYS | - |
dc.subject | STRESS | - |
dc.subject | DIFFERENTIATION | - |
dc.subject | TRANSPLANTATION | - |
dc.subject | ANGIOGENESIS | - |
dc.subject | KINASE | - |
dc.subject | FAMILY | - |
dc.title | Protective effects of hepatocyte growth factor gene overexpression against hydrogen peroxide-induced apoptosis in mesenchymal stem cells | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Park, See-Hyoung | - |
dc.identifier.doi | 10.1002/tox.22824 | - |
dc.identifier.scopusid | 2-s2.0-85069858510 | - |
dc.identifier.wosid | 000476068500001 | - |
dc.identifier.bibliographicCitation | ENVIRONMENTAL TOXICOLOGY, v.34, no.11, pp.1236 - 1245 | - |
dc.relation.isPartOf | ENVIRONMENTAL TOXICOLOGY | - |
dc.citation.title | ENVIRONMENTAL TOXICOLOGY | - |
dc.citation.volume | 34 | - |
dc.citation.number | 11 | - |
dc.citation.startPage | 1236 | - |
dc.citation.endPage | 1245 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Environmental Sciences & Ecology | - |
dc.relation.journalResearchArea | Toxicology | - |
dc.relation.journalResearchArea | Water Resources | - |
dc.relation.journalWebOfScienceCategory | Environmental Sciences | - |
dc.relation.journalWebOfScienceCategory | Toxicology | - |
dc.relation.journalWebOfScienceCategory | Water Resources | - |
dc.subject.keywordPlus | NADPH OXIDASES | - |
dc.subject.keywordPlus | CANCER | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | PATHWAYS | - |
dc.subject.keywordPlus | STRESS | - |
dc.subject.keywordPlus | DIFFERENTIATION | - |
dc.subject.keywordPlus | TRANSPLANTATION | - |
dc.subject.keywordPlus | ANGIOGENESIS | - |
dc.subject.keywordPlus | KINASE | - |
dc.subject.keywordPlus | FAMILY | - |
dc.subject.keywordAuthor | CRISPR | - |
dc.subject.keywordAuthor | hepatocyte growth factor | - |
dc.subject.keywordAuthor | mesenchymal stem cell | - |
dc.subject.keywordAuthor | reactive oxygen species | - |
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