Tyrosine-derived polycarbonate scaffolds for bone regeneration in a rabbit radius critical-size defect model
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Jinku | - |
dc.contributor.author | McBride, Sean | - |
dc.contributor.author | Donovan, Amy | - |
dc.contributor.author | Darr, Aniq | - |
dc.contributor.author | Magno, Maria Hanshella R. | - |
dc.contributor.author | Hollinger, Jeffrey O. | - |
dc.date.available | 2020-07-10T07:05:52Z | - |
dc.date.created | 2020-07-06 | - |
dc.date.issued | 2015-06 | - |
dc.identifier.issn | 1748-6041 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hongik/handle/2020.sw.hongik/9825 | - |
dc.description.abstract | The aim of the study was to determine bone regeneration in a rabbit radius critical-size defect (CSD) model using a specific polymer composition (E1001(1k)) from a library of tyrosine-derived polycarbonate scaffolds coated with a calcium phosphate (CP) formulation (E1001(1k) + CP) supplemented with recombinant human bone morphogenetic protein-2 (rhBMP-2). Specific doses of rhBMP-2 (0, 17, and 35 mu g/scaffold) were used. E1001(1k) + CP scaffolds were implanted in unilateral segmental defects (15 mm length) in the radial diaphyses of New Zealand White rabbits. At 4 and 8 weeks post-implantation, bone regeneration was determined using micro-computed tomography (mu CT), histology, and histomorphometry. The quantitative outcome data suggest that E1001(1k) + CP scaffolds with rhBMP-2 were biocompatible and promoted bone regeneration in segmental bone defects. Histological examination of the implant sites showed that scaffolds made of E1001(1k) + CP did not elicit adverse cellular or tissue responses throughout test periods up to 8 weeks. Noteworthy is that the incorporation of a very small amount of rhBMP-2 into the scaffolds (as low as 17 mu g/defect site) promoted significant bone regeneration compared to scaffolds consisting of E1001(1k) + CP alone. This finding indicates that E1001(1k) + CP may be an effective platform for bone regeneration in a critical size rabbit radius segmental defect model, requiring only a minimal dose of rhBMP-2. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | IOP PUBLISHING LTD | - |
dc.subject | MORPHOGENETIC PROTEIN-2 | - |
dc.subject | IN-VITRO | - |
dc.subject | PART I | - |
dc.subject | HYDROLYTIC DEGRADATION | - |
dc.subject | DELIVERY-SYSTEM | - |
dc.subject | BIOMATERIALS | - |
dc.subject | MATRIX | - |
dc.subject | GROWTH | - |
dc.subject | DIFFERENTIATION | - |
dc.subject | OSTEOBLASTS | - |
dc.title | Tyrosine-derived polycarbonate scaffolds for bone regeneration in a rabbit radius critical-size defect model | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Jinku | - |
dc.identifier.doi | 10.1088/1748-6041/10/3/035001 | - |
dc.identifier.scopusid | 2-s2.0-84933045481 | - |
dc.identifier.wosid | 000357093000015 | - |
dc.identifier.bibliographicCitation | BIOMEDICAL MATERIALS, v.10, no.3 | - |
dc.relation.isPartOf | BIOMEDICAL MATERIALS | - |
dc.citation.title | BIOMEDICAL MATERIALS | - |
dc.citation.volume | 10 | - |
dc.citation.number | 3 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Engineering | - |
dc.relation.journalResearchArea | Materials Science | - |
dc.relation.journalWebOfScienceCategory | Engineering, Biomedical | - |
dc.relation.journalWebOfScienceCategory | Materials Science, Biomaterials | - |
dc.subject.keywordPlus | MORPHOGENETIC PROTEIN-2 | - |
dc.subject.keywordPlus | IN-VITRO | - |
dc.subject.keywordPlus | PART I | - |
dc.subject.keywordPlus | HYDROLYTIC DEGRADATION | - |
dc.subject.keywordPlus | DELIVERY-SYSTEM | - |
dc.subject.keywordPlus | BIOMATERIALS | - |
dc.subject.keywordPlus | MATRIX | - |
dc.subject.keywordPlus | GROWTH | - |
dc.subject.keywordPlus | DIFFERENTIATION | - |
dc.subject.keywordPlus | OSTEOBLASTS | - |
dc.subject.keywordAuthor | tyrosine-derived polycarbonates | - |
dc.subject.keywordAuthor | E1001(1k) + CP | - |
dc.subject.keywordAuthor | bone regeneration | - |
dc.subject.keywordAuthor | rhBMP-2 | - |
dc.subject.keywordAuthor | rabbit radius critical-size defect | - |
dc.subject.keywordAuthor | bone tissue engineering | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
94, Wausan-ro, Mapo-gu, Seoul, 04066, Korea02-320-1314
COPYRIGHT 2020 HONGIK UNIVERSITY. ALL RIGHTS RESERVED.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.