Neurologic Effects of SARS-CoV-2 Transmitted among Dogsopen access
- Authors
- Dong-Hwi Kim; Da-Yoon Kim; Kyu-Sung Kim; Sang-Hoon Han; Hyeon-Jeong Go; Jae-Hyeong Kim; Kyu-Beom Lim; Dong-Hun Lee; Joong-Bok Lee; Seung-Yong Park; Chang-Seon Song; Sang-Won Lee; Yang-Kyu Choi; Yeun-Kyung Shin; Oh-Kyu Kwon; Do-Geun Kim; In-Soo Choi
- Issue Date
- Nov-2023
- Publisher
- US National Center for Infectious Diseases
- Citation
- Emerging Infectious Diseases
- Journal Title
- Emerging Infectious Diseases
- URI
- http://scholarworks.bwise.kr/kbri/handle/2023.sw.kbri/1033
- DOI
- 10.3201/eid2911.230804
- ISSN
- 1080-6040
- Abstract
- SARS-CoV-2 induces illness and death in humans by causing systemic infections. Evidence suggests that SARS-CoV-2 can induce brain pathology in humans and other hosts. In this study, we used a canine transmission model to examine histopathologic changes in the brains of dogs infected with SARS-CoV-2. We observed substantial brain pathology in SARS-CoV-2–infected dogs, particularly involving blood–brain barrier damage resembling small vessel disease, including changes in tight junction proteins, reduced laminin levels, and decreased pericyte coverage. Furthermore, we detected phosphorylated tau, a marker of neurodegenerative disease, indicating a potential link between SARS-CoV-2–associated small vessel disease and neurodegeneration. Our findings of degenerative changes in the dog brain during SARS-CoV-2 infection emphasize the potential for transmission to other hosts and induction of similar signs and symptoms. The dynamic brain changes in dogs highlight that even asymptomatic individuals infected with SARS-CoV-2 may develop neuropathologic changes in the brain.
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