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Distinct prefrontal projection activity and transcriptional state conversely orchestrate social competition and hierarchy

Authors
Choi, Tae-YongJeon, HyoungseokJeong, SejinKim, Eum JiKim, JeongseopJeong, Yun HaKang, ByungsooChoi, MurimKoo, Ja Wook
Issue Date
Feb-2024
Publisher
Cell Press
Citation
Neuron, v.111, no.4, pp 1 - 17
Pages
17
Journal Title
Neuron
Volume
111
Number
4
Start Page
1
End Page
17
URI
http://scholarworks.bwise.kr/kbri/handle/2023.sw.kbri/1136
DOI
10.1016/j.neuron.2023.11.012
ISSN
0896-6273
1097-4199
Abstract
Social animals compete for limited resources, resulting in a social hierarchy. Although different neuronal subpopulations in the medial prefrontal cortex (mPFC), which has been mechanistically implicated in social dominance behavior, encode distinct social competition behaviors, their identities and associated molecular underpinnings have not yet been identified. In this study, we found that mPFC neurons projecting to the nucleus accumbens (mPFC-NAc) encode social winning behavior, whereas mPFC neurons projecting to the ventral tegmental area (mPFC-VTA) encode social losing behavior. High -throughput single -cell transcriptomic analysis and projection -specific genetic manipulation revealed that the expression level of POU domain, class 3, transcription factor 1 (Pou3f1) in mPFC-VTA neurons controls social hierarchy. Optogenetic activation of mPFC-VTA neurons increases Pou3f1 expression and lowers social rank. Together, these data demonstrate that discrete activity and gene expression in separate mPFC projections oppositely orchestrate social competition and hierarchy.
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연구본부 > 퇴행성 뇌질환 연구그룹 > 1. Journal Articles
연구본부 > 신경·혈관 단위체 연구그룹 > 1. Journal Articles
연구본부 > 정서·인지 질환 연구그룹 > 1. Journal Articles

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