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Different resting membrane potentials in posterior parietal cortex and prefrontal cortex in the view of recurrent synaptic strengths and neural network dynamicsopen access

Authors
Yoo, MinsuYang, Yoon SilRah, Jong-CheolChoi, Joon Ho
Issue Date
Jul-2023
Publisher
FRONTIERS MEDIA SA
Keywords
membrane potential; PFC; PPC; working-memory; network dynamics
Citation
FRONTIERS IN CELLULAR NEUROSCIENCE, v.17
Journal Title
FRONTIERS IN CELLULAR NEUROSCIENCE
Volume
17
URI
http://scholarworks.bwise.kr/kbri/handle/2023.sw.kbri/114
DOI
10.3389/fncel.2023.1153970
ISSN
1662-5102
Abstract
In this study, we introduce the importance of elevated membrane potentials (MPs) in the prefrontal cortex (PFC) compared to that in the posterior parietal cortex (PPC), based on new observations of different MP levels in these areas. Through experimental data and spiking neural network modeling, we investigated a possible mechanism of the elevated membrane potential in the PFC and how these physiological differences affect neural network dynamics and cognitive functions in the PPC and PFC. Our findings indicate that NMDA receptors may be a main contributor to the elevated MP in the PFC region and highlight the potential of using a modeling toolkit to investigate the means by which changes in synaptic properties can affect neural dynamics and potentiate desirable cognitive functions through population activities in the corresponding brain regions.
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연구본부 > 감각·운동시스템 연구그룹 > 1. Journal Articles

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연구본부 (감각·운동시스템 연구그룹)
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