Detailed Information

Cited 0 time in webofscience Cited 0 time in scopus
Metadata Downloads

Effects of functional polymorphisms of opioid receptor mu 1 and catechol‐O‐methyltransferase on the neural processing of pain

Full metadata record
DC Field Value Language
dc.contributor.author정용전-
dc.contributor.author이선경-
dc.contributor.authorOkazawa, Hidehiko-
dc.contributor.authorKosaka, Hirotaka-
dc.contributor.author정민영-
dc.date.accessioned2024-03-07T01:30:11Z-
dc.date.available2024-03-07T01:30:11Z-
dc.date.issued2024-02-
dc.identifier.issn1323-1316-
dc.identifier.issn1440-1819-
dc.identifier.urihttp://scholarworks.bwise.kr/kbri/handle/2023.sw.kbri/1150-
dc.description.abstract<jats:sec><jats:title>Aim</jats:title><jats:p>Pain is reconstructed by brain activities and its subjectivity comes from an interplay of multiple factors. The current study aims to understand the contribution of genetic factors to the neural processing of pain. Focusing on the single‐nucleotide polymorphism (SNP) of opioid receptor mu 1 (OPRM1) <jats:italic>A</jats:italic><jats:sup><jats:italic>118</jats:italic></jats:sup><jats:italic>G</jats:italic> (rs1799971) and catechol‐O‐methyltransferase (COMT) <jats:italic>val</jats:italic><jats:sup><jats:italic>158</jats:italic></jats:sup><jats:italic>met</jats:italic> (rs4680), we investigated how the two pain genes affect pain processing.</jats:p></jats:sec><jats:sec><jats:title>Method</jats:title><jats:p>We integrated a genetic approach with functional neuroimaging. We extracted genomic DNA information from saliva samples to genotype the SNP of OPRM1 and COMT. We used a percept‐related model, in which two different levels of perceived pain intensities (“low pain: mildly painful” vs “high pain: severely painful”) were employed as experimental stimuli.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>Low pain involves a broader network relative to high pain. The distinct effects of pain genes were observed depending on the perceived pain intensity. The effects of low pain were found in supramarginal gyrus, angular gyrus, and anterior cingulate cortex (ACC) for OPRM1 and in middle temporal gyrus for COMT. For high pain, OPRM1 affected the insula and cerebellum, while COMT affected the middle occipital gyrus and ACC.</jats:p></jats:sec><jats:sec><jats:title>Conclusion</jats:title><jats:p>OPRM1 primarily affects sensory and cognitive components of pain processing, while COMT mainly influences emotional aspects of pain processing. The interaction of the two pain genes was associated with neural patterns coding for high pain and neural activation in the ACC in response to pain. The proteins encoded by the OPRM1 and COMT may contribute to the firing of pain‐related neurons in the human ACC, a critical center for subjective pain experience.</jats:p></jats:sec>-
dc.language영어-
dc.language.isoENG-
dc.publisherBlackwell Publishing Inc.-
dc.titleEffects of functional polymorphisms of opioid receptor mu 1 and catechol‐O‐methyltransferase on the neural processing of pain-
dc.typeArticle-
dc.publisher.location미국-
dc.identifier.doi10.1111/pcn.13648-
dc.identifier.wosid001175382700001-
dc.identifier.bibliographicCitationPsychiatry and Clinical Neurosciences-
dc.citation.titlePsychiatry and Clinical Neurosciences-
dc.type.docTypeArticle; Early Access-
dc.description.isOpenAccessN-
dc.description.journalRegisteredClassscie-
dc.relation.journalResearchAreaNeurosciences & Neurology-
dc.relation.journalResearchAreaPsychiatry-
dc.relation.journalWebOfScienceCategoryClinical Neurology-
dc.relation.journalWebOfScienceCategoryNeurosciences-
dc.relation.journalWebOfScienceCategoryPsychiatry-
dc.subject.keywordPlusSINGLE-NUCLEOTIDE POLYMORPHISM-
dc.subject.keywordPlusANTERIOR CINGULATE CORTEX-
dc.subject.keywordPlusOPRM1 A118G-
dc.subject.keywordPlusSUBJECTIVE EXPERIENCE-
dc.subject.keywordPlusBRAIN-REGIONS-
dc.subject.keywordPlusGENE-
dc.subject.keywordPlusPERCEPTION-
dc.subject.keywordPlusFMRI-
dc.subject.keywordPlusMETAANALYSIS-
dc.subject.keywordPlusINFORMATION-
dc.subject.keywordAuthorbrain and pain-
dc.subject.keywordAuthorcatechol-O-methyltransferase-
dc.subject.keywordAuthoropioid receptor mu 1-
Files in This Item
There are no files associated with this item.
Appears in
Collections
연구본부 > 인지과학 연구그룹 > 1. Journal Articles

qrcode

Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.

Related Researcher

Researcher Jung, Min young photo

Jung, Min young
연구본부 (인지과학 연구그룹)
Read more

Altmetrics

Total Views & Downloads

BROWSE