Detailed Information

Cited 0 time in webofscience Cited 0 time in scopus
Metadata Downloads

Molecular and cellular basis of sodium sensing in Drosophila labellumopen access

Authors
Wayessa Rahel AsefaJin-Nyeong WooKim, Seon YeongHyungjun ChoiHayeon SungMin Sung ChoiMinkook ChoiSung-Eun YoonYoung-Joon KimByung-Chang SuhKang, Kyeong JinJae Young Kwon
Issue Date
Jul-2024
Publisher
CELL PRESS
Citation
ISCIENCE, v.27, no.7
Journal Title
ISCIENCE
Volume
27
Number
7
URI
http://scholarworks.bwise.kr/kbri/handle/2023.sw.kbri/1184
DOI
10.1016/j.isci.2024.110248
ISSN
2589-0042
Abstract
Appropriate ingestion of salt is essential for physiological processes such as ionic homeostasis and neuronal activity. Generally, low concentrations of salt elicit attraction, while high concentrations elicit aversive responses. Here, we observed that sugar neurons in the L sensilla of the Drosophila labellum cf. responses to NaCl, while sugar neurons in the S-c sensilla do not respond to NaCl, suggesting that gustatory receptor neurons involved in NaCl sensing may employ diverse molecular mechanisms. Through an RNAi screen of the entire Ir and ppk gene families and molecular genetic approaches, we identified IR76b, IR25a, and IR56b as necessary components for NaCl sensing in the Drosophila labellum. Co-expression of these three IRs in heterologous systems such as S2 cells or Xenopus oocytes resulted in a current in response to sodium stimulation, suggesting formation of a sodium-sensing complex. Our results should provide insights for research on the diverse combinations constituting salt receptor complexes.
Files in This Item
There are no files associated with this item.
Appears in
Collections
연구본부 > 신경·혈관 단위체 연구그룹 > 1. Journal Articles

qrcode

Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.

Related Researcher

Researcher Kang, Kyeong Jin photo

Kang, Kyeong Jin
연구본부 (신경·혈관단위체 연구그룹)
Read more

Altmetrics

Total Views & Downloads

BROWSE