Comparative anatomy of the dentate mossy cells in non-human primates: their spatial distributions and axonal projections compared with mouse mossy cellsopen access
- Authors
- Jeong, Minseok; Won, Jinyoung; Lim, Kyung Seob; Jeon, Chang-Yeop; Choe, Youngshik; Jang, Jin-Hyeok; Ha, Chang Man; Yoon, Jong Hyuk; Lee, Yongjeon; Oh, Yong-Seok
- Issue Date
- May-2024
- Publisher
- SOC NEUROSCIENCE
- Keywords
- associational projections; commissural projections; dentate gyrus; heterogeneity; hippocampus; mossy cells
- Citation
- eNeuro, v.11, no.5, pp ENEURO.0151 - 24.2024
- Journal Title
- eNeuro
- Volume
- 11
- Number
- 5
- Start Page
- ENEURO.0151
- End Page
- 24.2024
- URI
- http://scholarworks.bwise.kr/kbri/handle/2023.sw.kbri/1185
- DOI
- 10.1523/eneuro.0151-24.2024
- ISSN
- 2373-2822
- Abstract
- Glutamatergic mossy cells (MCs) mediate associational and commissural connectivity, exhibiting significant heterogeneity along the septotemporal axis of the mouse dentate gyrus (DG). However, it remains unclear whether the neuronal features of MCs are conserved across mammals. This study compares the neuroanatomy of MCs in the DG of mice and monkeys. The MC marker, calretinin, distinguishes two subpopulations: septal and temporal. Dual-colored fluorescence labeling is utilized to compare the axonal projection patterns of these subpopulations. In both mice and monkeys, septal and temporal MCs project axons across the longitudinal axis of the ipsilateral DG, indicating conserved associational projections. However, unlike in mice, no MC subpopulations in monkeys make commissural projections to the contralateral DG. In monkeys, temporal MCs send associational fibers exclusively to the inner molecular layer, while septal MCs give rise to wide axonal projections spanning multiple molecular layers, akin to equivalent MC subpopulations in mice. Despite conserved septotemporal heterogeneity, interspecies differences are observed in the topological organization of septal MCs, particularly in the relative axonal density in each molecular layer along the septotemporal axis of the DG. In summary, this comparative analysis sheds light on both conserved and divergent features of MCs in the DG of mice and monkeys. These findings have implications for understanding functional differentiation along the septotemporal axis of the DG and contribute to our knowledge of the anatomical evolution of the DG circuit in mammals.
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - 연구본부 > 퇴행성 뇌질환 연구그룹 > 1. Journal Articles
- 연구전략실 > 연구전략실 > 1. Journal Articles
![qrcode](https://api.qrserver.com/v1/create-qr-code/?size=55x55&data=http://scholarworks.bwise.kr/kbri/handle/2023.sw.kbri/1185)
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.