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Structural development and brain asymmetry in the fronto-limbic regions in preschool-aged children

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dc.contributor.authorLee, Gang Yi-
dc.contributor.authorYoun, Young-Ah-
dc.contributor.authorJang, Yong Hun-
dc.contributor.authorKim, Hyuna-
dc.contributor.authorLee, Joo Young-
dc.contributor.authorLee, Young Jun-
dc.contributor.authorJung, Minyoung-
dc.contributor.authorLee, Hyun Ju-
dc.date.accessioned2024-10-18T01:30:12Z-
dc.date.available2024-10-18T01:30:12Z-
dc.date.issued2024-10-
dc.identifier.issn2296-2360-
dc.identifier.urihttp://scholarworks.bwise.kr/kbri/handle/2023.sw.kbri/1199-
dc.description.abstract<jats:p>Early-life experiences play a crucial role in the development of the fronto-limbic regions, influencing both macro- and microstructural changes in the brain. These alterations profoundly impact cognitive, social-emotional functions. Recently, early limbic structural alterations have been associated with numerous neurological and psychiatric morbidities. Although identifying normative developmental trajectories is essential for determining brain alterations, only a few studies have focused on examining the normative trajectories in the fronto-limbic regions during preschool-aged children. The aim of this study was to investigate the structural-developmental trajectory of the fronto-limbic regions using the cortical thickness, volume, and subcortical volume in 57 healthy and typical preschool-aged children between 1 and 5 years and examined the early lateralization patterns during the development of the fronto-limbic regions. Regarding brain lateralization, remarkable asymmetry was detected in the volume of thalamus and the cortical regions excluding the lateral orbitofrontal cortex in the fronto-limbic regions. This study of preschool-aged children may fill the knowledge gaps regarding the developmental patterns and hemispheric asymmetries of the fronto-limbic regions between newborns and adolescents.</jats:p>-
dc.language영어-
dc.language.isoENG-
dc.publisherFrontiers Media S.A.-
dc.titleStructural development and brain asymmetry in the fronto-limbic regions in preschool-aged children-
dc.typeArticle-
dc.publisher.location스위스-
dc.identifier.doi10.3389/fped.2024.1362409-
dc.identifier.bibliographicCitationFrontiers in Pediatrics, v.12-
dc.citation.titleFrontiers in Pediatrics-
dc.citation.volume12-
dc.description.isOpenAccessY-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
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