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GluN2B-mediated regulation of silent synapses for receptor specification and addiction memory

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dc.contributor.authorKim, Hyun Jin-
dc.contributor.authorLee, Sangjun-
dc.contributor.authorKim, Gyu Hyun-
dc.contributor.authorSung, Kibong-
dc.contributor.authorYoo, Taesik-
dc.contributor.authorPyo, Jung Hyun-
dc.contributor.authorJo, Hee-Jung-
dc.contributor.authorLee, Sanghyeon-
dc.contributor.authorLee, Hyun-Young-
dc.contributor.authorJung, Jung Hoon-
dc.contributor.authorLee, Kea Joo-
dc.contributor.authorKim, Joung-Hun-
dc.date.accessioned2025-03-05T00:00:07Z-
dc.date.available2025-03-05T00:00:07Z-
dc.date.issued2025-02-
dc.identifier.issn1226-3613-
dc.identifier.issn2092-6413-
dc.identifier.urihttp://scholarworks.bwise.kr/kbri/handle/2023.sw.kbri/1247-
dc.description.abstractPsychostimulants, including cocaine, elicit stereotyped, addictive behaviors. The reemergence of silent synapses containing only NMDA-type glutamate receptors is a critical mediator of addiction memory and seeking behaviors. Despite the predominant abundance of GluN2B-containing NMDA-type glutamate receptors in silent synapses, their operational mechanisms are not fully understood. Here, using conditional depletion/deletion of GluN2B in D1-expressing accumbal medium spiny neurons, we examined the synaptic and behavioral actions that silent synapses incur after repeated exposure to cocaine. GluN2B ablation reduces the proportion of silent synapses, but some of them can persist by substitution with GluN2C, which drives the aberrantly facilitated synaptic incorporation of calcium-impermeable AMPA-type glutamate receptors (AMPARs). The resulting precocious maturation of silent synapses impairs addiction memory but increases locomotor activity, both of which can be normalized by the blockade of calcium-impermeable AMPAR trafficking. Collectively, GluN2B supports the competence of cocaine-induced silent synapses to specify the subunit composition of AMPARs and thereby the expression of addiction memory and related behaviors.-
dc.format.extent14-
dc.publisherSpringer Nature-
dc.titleGluN2B-mediated regulation of silent synapses for receptor specification and addiction memory-
dc.typeArticle-
dc.publisher.location대한민국-
dc.identifier.doi10.1038/s12276-025-01399-z-
dc.identifier.wosid001416951200001-
dc.identifier.bibliographicCitationExperimental & Molecular Medicine, v.57, pp 436 - 449-
dc.citation.titleExperimental & Molecular Medicine-
dc.citation.volume57-
dc.citation.startPage436-
dc.citation.endPage449-
dc.type.docTypeArticle; Early Access-
dc.identifier.kciidART003179894-
dc.description.isOpenAccessN-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.description.journalRegisteredClasskci-
dc.relation.journalResearchAreaBiochemistry & Molecular Biology-
dc.relation.journalResearchAreaResearch & Experimental Medicine-
dc.relation.journalWebOfScienceCategoryBiochemistry & Molecular Biology-
dc.relation.journalWebOfScienceCategoryMedicine, Research & Experimental-
dc.subject.keywordPlusCONDITIONED PLACE PREFERENCE-
dc.subject.keywordPlusNMDA-RECEPTOR-
dc.subject.keywordPlusAMPA RECEPTORS-
dc.subject.keywordPlusSURFACE EXPRESSION-
dc.subject.keywordPlusCOCAINE-
dc.subject.keywordPlusSUBUNIT-
dc.subject.keywordPlusTRAFFICKING-
dc.subject.keywordPlusPLASTICITY-
dc.subject.keywordPlusAMYGDALA-
dc.subject.keywordPlusNEURONS-
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