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A Highly Efficient Low-Cost Flexible Neural Probe for Scalable Mass Fabrication

Authors
Lee, HaeyunLee, SeungbinLee, SeungjunLee, Jimin추남선Shin, Hyogeun
Issue Date
Mar-2025
Publisher
ACS Publications
Citation
ACS Omega, v.10, no.10, pp 10733 - 10740
Pages
8
Journal Title
ACS Omega
Volume
10
Number
10
Start Page
10733
End Page
10740
URI
http://scholarworks.bwise.kr/kbri/handle/2023.sw.kbri/1256
DOI
10.1021/acsomega.5c01419
ISSN
2470-1343
2470-1343
Abstract
Neural probes capable of the precise recording and control of brain signals are essential tools for brain–computer interfaces and neuroscience research. However, conventional neural probes have not been widely adopted due to the high costs associated with semiconductor fabrication and complex packaging procedures. Herein, we present a breakthrough in this area in the form of a highly efficient flexible neural probe with a production cost of only 1.5 dollars per unit that can be mass-produced (1000 units within 3 days). The probe design is based on a standardized flexible printed circuit board (PCB) process that ensures large-scale producibility and minimizes device performance variation. The device features four independent neural probes that enable flexible targeting of multiple brain regions and a reusable interface PCB that minimizes packaging complexity. The neural signal recording performance of the fabricated probe is comparable to that of traditional silicon-based probes and is scalable with eight electrodes capable of simultaneous measurements. We anticipate that our innovative device will significantly improve the accessibility of neuroscience research.
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