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Utility of hypervariable region in hepatitis E virus for genetic evolution analysis and epidemiological studies

Authors
Kim, Dong-HwiKim, Da-YoonKim, Jae-HyeongLim, Kyu-BeomCho, Andrew Y.Lee, Joong-BokPark, Seung-YongSong, Chang- SeonLee, Sang-WonLee, Dong-HunKim, Do-GeunChoi, In-Soo
Issue Date
Feb-2025
Publisher
Society for General Microbiology
Keywords
epidemiology; genetic evolution; hepatitis E virus; hypervariable region; phylogenetic analysis
Citation
Journal of General Virology, v.106, no.2
Journal Title
Journal of General Virology
Volume
106
Number
2
URI
http://scholarworks.bwise.kr/kbri/handle/2023.sw.kbri/1257
DOI
10.1099/jgv.0.002080
ISSN
0022-1317
1465-2099
Abstract
Clinical and experimental studies have advanced our understanding of hepatitis E virus (HEV) infection; however, translating the findings to improve prevention and clinical outcomes remains challenging. Phylogenetic analyses of HEV show inconsistencies due to variations in the nucleotide regions studied. This study examined specific HEV regions to facilitate comprehensive molecular and phylogenetic analyses by examining the complete genome and commonly studied partial genome regions. We compared topological similarities between phylogenetic trees and evaluated evolutionary divergence using base substitutions and pairwise distances. The hypervariable region (HVR) showed the closest topology (Robinson-Foulds, Jaccard Robinson- Foulds and clustering information) to the complete genome and a higher mutation rate, resulting in longer branch lengths and clearer genotypic distinctions. Pairwise analysis revealed greater intra- and intergenotypic diversity in the HVR than in other regions. The higher base substitution rate and longer branch lengths of HVR suggest its key role in genotype evolution. Classifying HEV using HVR instead of the other partial genomic regions can reveal subtypes that more accurately reflect the genetic characteristics of HEV. Future research could focus on HVRs to better compare clinical symptoms and genetic features of HEV.
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