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A Neurospheroid-Based Microrobot for Targeted Neural Connections in a Hippocampal Slice

Authors
Rah, Jong-CheolEunhee KimSungwoong JeonYoon-Sil YangChaewon JinJin-Young KimYong-Seok OhChoi, Hongsoo
Issue Date
Feb-2023
Publisher
WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Keywords
high-density multi-electrode arrays; magnetic manipulation; neurospheroids; organotypic hippocampal slice; superparamagnetic iron oxide nanoparticles
Citation
Advanced Materials
Journal Title
Advanced Materials
URI
http://scholarworks.bwise.kr/kbri/handle/2023.sw.kbri/163
DOI
10.1002/adma.202208747
ISSN
0935-9648
Abstract
Functional restoration by the re-establishment of cellular or neural connections remains a major challenge in targeted cell therapy and regenerative medicine. Recent advances in magnetically powered microrobots have shown potential for use in controlled and targeted cell therapy. In this study, a magnetic neurospheroid (Mag-Neurobot) that could form both structural and functional connections with an organotypic hippocampal slice (OHS) was assessed using an ex vivo model as a bridge toward in vivo application. The Mag-Neurobot consists of hippocampal neurons and superparamagnetic nanoparticles (SPIONs); it is precisely and skillfully manipulated by an external magnetic field. Furthermore, the results of patch-clamp recordings of hippocampal neurons indicated that neither the neuronal excitabilities nor the synaptic functions of SPION-loaded cells were significantly affected. Analysis of neural activity propagation using high-density multi-electrode arrays showed that the delivered Mag-Neurobot was functionally connected with the OHS. The applications of this study include functional verification for targeted cell delivery through the characterization of novel synaptic connections and the functionalities of transported and transplanted cells. The success of the Mag-Neurobot opens up new avenues of research and application; it offers a test platform for functional neural connections and neural regenerative processes through cell transplantation. This article is protected by copyright. All rights reserved.
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연구본부 (감각·운동시스템 연구그룹)
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