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LRRK2 decreases microglial actin dynamics by filamentous actin depolymerization and Rac1 inhibitionopen access
- Authors
- Kim, Beomsue; Suh, Young Ho; Joe, Eunhye
- Issue Date
- Dec-2022
- Publisher
- 한국통합생물학회
- Keywords
- Actin depolymerization; F-actin-binding proteins; Leucine-rich repeat serine-threonine protein kinase-2; Parkinson disease 8; microglia
- Citation
- Animal Cells and Systems, v.26, no.6, pp 380 - 387
- Pages
- 8
- Journal Title
- Animal Cells and Systems
- Volume
- 26
- Number
- 6
- Start Page
- 380
- End Page
- 387
- ISSN
- 1976-8354
2151-2485
- Abstract
- An active actin dynamic is a crucial feature of brain microglia. Here we report that LRRK2, a primary familial Parkinson's disease-associated gene, negatively regulates microglia's actin dynamics. LRRK2 depolymerized filamentous actin (F-actin) by directly binding to it or inhibiting microglia's Rac-PAK signaling. LRRK2 knockdown resulted in a reduced ruffle and enhanced lamellipodia formation of ADP-activated microglia, altering the microglia's physiological activity to vigorous migration toward damaged cells. These results suggest that LRRK2 is a negative regulator for the controlled actin dynamics in microglia.
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