뇌척수액 미세순환을 통한 래트 내이 외림프의 가돌리늄 조영제 증강 특성Enhancement Characteristics of Gadolinium Contrast Agent in the Rat Inner Ear Perilymph through CSF microcirculation
- Other Titles
- Enhancement Characteristics of Gadolinium Contrast Agent in the Rat Inner Ear Perilymph through CSF microcirculation
- Authors
- 김민정; 이상열; 이희중; 이태관; 장용민
- Issue Date
- Aug-2022
- Publisher
- 대한의용생체공학회
- Keywords
- Intracerebroventricular administration; Gadolinium-based contrast agent; Endolymphatic hydrops; CSF
- Citation
- 의공학회지, v.43, no.4, pp.193 - 198
- Journal Title
- 의공학회지
- Volume
- 43
- Number
- 4
- Start Page
- 193
- End Page
- 198
- URI
- http://scholarworks.bwise.kr/kbri/handle/2023.sw.kbri/208
- ISSN
- 1229-0807
- Abstract
- Contrast enhanced magnetic resonance imaging using gadolinium-based contrast agent (GBCA) is a very useful in vivo technique to visualize the inner ear pathology including endolymphatic hydrops. Although systemic intravenous (IV) administration can visualize the perilymph space, the visualization was possible by indirect passage of contrast agent through blood–perilymph barrier. All animal experimental procedures were performed under anesthesia with 5% isoflurane. Lipopolysaccharide (LPS) was instilled into the left tympanic cavity through the tympanic membrane using a sterile 27gauge needle to induce hydrops model. Tucker-Davis Technologies system was used to measure Auditory Brainstem Responses (ABRs). For intracerebroven- tricular (ICV) administration, 25 µmol of GADOVIST (Bayer, Berlin, Germany) was used and diluted GADOVIST injection was 10 µl. MR imaging was acquired with a 9.4 Tesla MRI scanner. Transmit- receive volume coil with 40 mm inner diameter and 75 mm out diameter was used. ICV administration well demonstrated the strong enhancement along the cerebrospinal fluid (CSF) microcirculation pathway including CSF fluid in the subarachnoid space and CSF space of the inner ear structures. On the other hand, IV administration showed no contrast enhancement along the CSF microcirculation pathway and showed weak enhancement in the inner ear structures. In case of rat hydrops model, ICV administration showed that the reduced contrast enhancement in the perilymph space of the hydrops induced inner ear compared to the contrast enhancement in the perilymph space of the normal inner ear. New systemic ICV administration method provide contrast enhancement of GBCA in the inner ear through CSF micro- circulation pathway.
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - 연구전략실 > 첨단뇌연구장비센터 > 1. Journal Articles
![qrcode](https://api.qrserver.com/v1/create-qr-code/?size=55x55&data=http://scholarworks.bwise.kr/kbri/handle/2023.sw.kbri/208)
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.