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Donepezil ameliorates A beta pathology but not tau pathology in 5xFAD mice

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dc.contributor.authorChoi, Hee-Jeong-
dc.contributor.authorPark, Jin-Hee-
dc.contributor.authorJeong, Yoo Joo-
dc.contributor.authorHwang, Jeong-Woo-
dc.contributor.authorLee, Soojung-
dc.contributor.authorLee, Heeyong-
dc.contributor.authorSeol, Eunyoung-
dc.contributor.authorKim, Ik-whi-
dc.contributor.authorCha, Byung-Yoon-
dc.contributor.authorSeo, Jinsoo-
dc.contributor.authorMoon, Minho-
dc.contributor.authorHoe, Hyang-Sook-
dc.date.accessioned2023-08-16T09:30:12Z-
dc.date.available2023-08-16T09:30:12Z-
dc.date.created2022-07-26-
dc.date.issued2022-07-
dc.identifier.issn1756-6606-
dc.identifier.urihttp://scholarworks.bwise.kr/kbri/handle/2023.sw.kbri/217-
dc.description.abstractThe cholinesterase inhibitor donepezil is used to improve A beta pathology and cognitive function in patients with Alzheimer's disease (AD). However, the impact of donepezil on tau pathology is unclear. Thus, we examined the effects of donepezil on A beta and tau pathology in 5xFAD mice (a model of AD) in this study. We found that intraperitoneal injection of donepezil (1 mg/kg, i.p.) exhibited significant reductions in A beta plaque number in the cortex and hippocampal DG region. In addition, donepezil treatment (1 mg/kg, i.p.) reduced A beta-mediated microglial and, to a lesser extent, astrocytic activation in 5xFAD mice. However, neither intraperitoneal/oral injection of donepezil nor oral injection of rivastigmine altered tau phosphorylation at Thr212/Ser214 (AT100), Thr396, and Thr231 in 5xFAD mice. Surprisingly, we observed that intraperitoneal/oral injection of donepezil treatment significantly increased tau phosphorylation at Thr212 in 5xFAD mice. Taken together, these data suggest that intraperitoneal injection of donepezil suppresses A beta pathology but not tau pathology in 5xFAD mice.-
dc.language영어-
dc.language.isoen-
dc.publisherBioMed Central-
dc.titleDonepezil ameliorates A beta pathology but not tau pathology in 5xFAD mice-
dc.typeArticle-
dc.contributor.affiliatedAuthorPark, Jin-Hee-
dc.contributor.affiliatedAuthorHoe, Hyang-Sook-
dc.identifier.doi10.1186/s13041-022-00948-1-
dc.identifier.scopusid2-s2.0-85134395260-
dc.identifier.wosid000826974100002-
dc.identifier.bibliographicCitationMolecular Brain, v.15, no.1-
dc.relation.isPartOfMolecular Brain-
dc.citation.titleMolecular Brain-
dc.citation.volume15-
dc.citation.number1-
dc.type.rimsART-
dc.type.docTypeArticle-
dc.description.journalClass1-
dc.description.isOpenAccessY-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.relation.journalResearchAreaNeurosciences & Neurology-
dc.relation.journalWebOfScienceCategoryNeurosciences-
dc.subject.keywordAuthorAlzheimer&apos-
dc.subject.keywordAuthors disease-
dc.subject.keywordAuthorTau-
dc.subject.keywordAuthorTau kinase-
dc.subject.keywordAuthorAmyloid beta-
dc.subject.keywordAuthor5xFAD mice-
dc.subject.keywordAuthorDonepezil-
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연구본부 (퇴행성뇌질환 연구그룹)
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