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Changes in Cytochrome C Oxidase Redox State and Hemoglobin Concentration in Rat Brain During 810 nm Irradiation Measured by Broadband Near-Infrared Spectroscopy

Authors
Oh, YoonhoNguyen, NamJung, Hyun JinChoe, YoungshikKim, Jae Gwan
Issue Date
May-2022
Publisher
Mary Ann Liebert Inc.
Keywords
photobiomodulation; bb-NIRS; cerebral hemodynamic; cerebral metabolism; 810 nm LED
Citation
Photobiomodulation, Photomedicine, and Laser Surgery, v.40, no.5, pp.315 - 324
Journal Title
Photobiomodulation, Photomedicine, and Laser Surgery
Volume
40
Number
5
Start Page
315
End Page
324
URI
http://scholarworks.bwise.kr/kbri/handle/2023.sw.kbri/233
DOI
10.1089/photob.2021.0089
Abstract
Objective: The effects of 810 nm light-emitting diode (LED) photobiomodulation (PBM) on cerebral metabolism and cerebral hemodynamic were investigated by using a broadband near-infrared spectroscopy (bb-NIRS) under anesthesia conditions with isoflurane.& nbsp;Background data: PBM was supposed to increase cerebral hemodynamic and cerebral metabolism. There has been no study about the effect of 810 nm LED stimulation on cerebral hemodynamic and cerebral metabolism in vivo by using bb-NIRS measurement.& nbsp;Methods: PBM was applied to seven Sprague-Dawley rats at 50 mW/cm(2) power density. The changes in hemoglobin concentration (delta[HbO(2)] and (delta[H;HHb) and oxidized cytochrome c oxidase (CCO) concentration ((delta[oxCCO]) were measured using a bb-NIRS. The total hemoglobin and the difference in hemoglobin concentration changes were calculated by summation and difference of & UDelta;HbO2 and & UDelta;HHb, respectively.& nbsp;Results: PBM evoked the gradual increases of & nbsp; (delta[HbO(2)] (+7.7 mu M vs. baseline, p = 0.008), delta[HbT] (+9.5 mu M vs. baseline, p = 0.0044), and (delta HbD) (+5.9 mu M vs. baseline, p > 0.05) during light stimulation. Meanwhile, delta[oxCCO] (-3.5 mu M vs. baseline, p = 0.0019) was significantly decreased right after the onset of stimulation.& nbsp;Conclusions: PBM with 810 nm LED (50 mW/cm(2)) increased cerebral oxygenation and blood volume as expected. However, oxidized CCO concentration was decreased, which was contrary to most previous studies. The two pathways of PBM effects on mitochondria and the inhibition of complex I by isoflurane were suggested to explain the decreased (delta[oxCCO] during PBM, but further study is required for the verification.
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연구본부 (뇌발달질환 연구그룹)
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