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Distinct Firing Activities of the Hypothalamic Arcuate Nucleus Neurons to Appetite Hormonesopen access

Authors
Na, JunewooPark, Byong SeoJang, DoohyeongKim, DonggueTu, Thai HienRyu, YoungjaeHa, Chang ManKoch, MarcoYang, SungchilKim, Jae GeunYang, Sunggu
Issue Date
Mar-2022
Publisher
Multidisciplinary Digital Publishing Institute (MDPI)
Keywords
AgRP; POMC; dopamine; ghrelin; leptin; appetite
Citation
International Journal of Molecular Sciences, v.23, no.5
Journal Title
International Journal of Molecular Sciences
Volume
23
Number
5
URI
http://scholarworks.bwise.kr/kbri/handle/2023.sw.kbri/242
DOI
10.3390/ijms23052609
ISSN
1661-6596
Abstract
The hypothalamic arcuate nucleus (Arc) is a central unit that controls the appetite through the integration of metabolic, hormonal, and neuronal afferent inputs. Agouti-related protein (AgRP), proopiomelanocortin (POMC), and dopaminergic neurons in the Arc differentially regulate feeding behaviors in response to hunger, satiety, and appetite, respectively. At the time of writing, the anatomical and electrophysiological characterization of these three neurons has not yet been intensively explored. Here, we interrogated the overall characterization of AgRP, POMC, and dopaminergic neurons using genetic mouse models, immunohistochemistry, and whole-cell patch recordings. We identified the distinct geographical location and intrinsic properties of each neuron in the Arc with the transgenic lines labelled with cell-specific reporter proteins. Moreover, AgRP, POMC, and dopaminergic neurons had different firing activities to ghrelin and leptin treatments. Ghrelin led to the increased firing rate of dopaminergic and AgRP neurons, and the decreased firing rate of POMC. In sharp contrast, leptin resulted in the decreased firing rate of AgRP neurons and the increased firing rate of POMC neurons, while it did not change the firing rate of dopaminergic neurons in Arc. These findings demonstrate the anatomical and physiological uniqueness of three hypothalamic Arc neurons to appetite control.
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