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Target identification of mouse stem cell probe CDy1 as ALDH2 and Abcb1b through live-cell affinity-matrix and ABC CRISPRa library
- Authors
- Miyamoto, Naoki; Go, Young-Hyun; Ciaramicoli, Larissa Miasiro; Kwon, Haw-Young; Kim, Heon Seok; Bi, Xuezhi; Yu, Young Hyun; Kim, Beomsue; Ha, Hyung-Ho; Kang, Nam-Young; Yun, Seong-Wook; Kim, Jin-Soo; Cha, Hyuk-Jin; Chang, Young-Tae
- Issue Date
- Dec-2021
- Publisher
- ROYAL SOC CHEMISTRY
- Citation
- RSC CHEMICAL BIOLOGY, v.2, no.6
- Journal Title
- RSC CHEMICAL BIOLOGY
- Volume
- 2
- Number
- 6
- ISSN
- 2633-0679
- Abstract
- CDy1 is a powerful tool to distingusih embryonic stem cells for reprogramming studies and regeneration medicine. However, the stem cell selectivity mechanism of CDy1 has not been fully understood. Here, we report ALDH2 and ABCB1 as the molecular targets of CDy1, elucidated by live-cell affinity-matrix and ABC transporter CRISPRa library screening. The two unique orthogonal mechanisms provide the potential of multi-demensional cellular distinction of specific cell types.
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