Detailed Information

Cited 11 time in webofscience Cited 9 time in scopus
Metadata Downloads

Regulation of habenular G-protein gamma 8 on learning and memory via modulation of the central acetylcholine system

Authors
Lee, Hyun-juChoi, Tae-IkKim, Yong-MinLee, SoonjeHan, BingBak, In SeonMoon, Sun AeYu, Dae-YeulShin, Ki SoonKwon, Yunhee KimMoon, CheilRyu, Jae HwanHoe, Hyang-SookKim, Cheol-HeeShim, Insop
Issue Date
Aug-2021
Publisher
SPRINGERNATURE
Citation
MOLECULAR PSYCHIATRY, v.26, no.8, pp.3737 - 3750
Journal Title
MOLECULAR PSYCHIATRY
Volume
26
Number
8
Start Page
3737
End Page
3750
URI
http://scholarworks.bwise.kr/kbri/handle/2023.sw.kbri/306
DOI
10.1038/s41380-020-00893-2
ISSN
1359-4184
Abstract
Guanine nucleotide binding protein (G protein) gamma 8 (Gng8) is a subunit of G proteins and expressed in the medial habenula (MHb) and interpeduncular nucleus (IPN). Recent studies have demonstrated that Gng8 is involved in brain development; however, the roles of Gng8 on cognitive function have not yet been addressed. In the present study, we investigated the expression of Gng8 in the brain and found that Gng8 was predominantly expressed in the MHb-IPN circuit of the mouse brain. We generatedGng8knockout (KO) mice by CRISPR/Cas9 system in order to assess the role of Gng8 on cognitive function.Gng8KO mice exhibited deficiency in learning and memory in passive avoidance and Morris water maze tests. In addition,Gng8KO mice significantly reduced long-term potentiation (LTP) in the hippocampus compared to that of wild-type (WT) mice. Furthermore, we observed that levels of acetylcholine (ACh) and choline acetyltransferase (ChAT) in the MHb and IPN ofGng8KO mice were significantly decreased, compared to WT mice. The administration of nAChR alpha 4 beta 2 agonist A85380 rescued memory impairment in theGng8KO mice, suggesting that Gng8 regulates cognitive function via modulation of cholinergic activity. Taken together, Gng8 is a potential therapeutic target for memory-related diseases and/or neurodevelopmental diseases.
Files in This Item
There are no files associated with this item.
Appears in
Collections
연구본부 > 퇴행성 뇌질환 연구그룹 > 1. Journal Articles

qrcode

Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.

Related Researcher

Researcher Lee, Hyun ju photo

Lee, Hyun ju
연구본부 (퇴행성뇌질환 연구그룹)
Read more

Altmetrics

Total Views & Downloads

BROWSE