Detailed Information

Cited 0 time in webofscience Cited 0 time in scopus
Metadata Downloads

Multi-Racial Normative Data for Lobar and Subcortical Brain Volumes in Old Age: Korean and Caucasian Norms May Be Incompatible With Each Other

Full metadata record
DC Field Value Language
dc.contributor.authorChoi, Yu Yong-
dc.contributor.authorLee, Jang Jae-
dc.contributor.authorChoi, Kyu Yeong-
dc.contributor.authorChoi, Uk-Su-
dc.contributor.authorSeo, Eun Hyun-
dc.contributor.authorChoo, I. L. Han-
dc.contributor.authorKim, Hoowon-
dc.contributor.authorSong, Min-Kyung-
dc.contributor.authorChoi, Seong-Min-
dc.contributor.authorCho, Soo Hyun-
dc.contributor.authorChoe, Youngshik-
dc.contributor.authorKim, Byeong C.-
dc.contributor.authorLee, Kun Ho-
dc.date.accessioned2023-08-16T09:31:17Z-
dc.date.available2023-08-16T09:31:17Z-
dc.date.created2022-01-11-
dc.date.issued2021-08-
dc.identifier.issn1663-4365-
dc.identifier.urihttp://scholarworks.bwise.kr/kbri/handle/2023.sw.kbri/310-
dc.description.abstractBrain aging is becoming an increasingly important topic, and the norms of brain structures are essential for diagnosing neurodegenerative diseases. However, previous studies of the aging brain have mostly focused on Caucasians, not East Asians. The aim of this paper was to examine ethnic differences in the aging process of brain structures or to determine to what extent ethnicity affects the normative values of lobar and subcortical volumes in clinically normal elderly and the diagnosis in multi-racial patients with Alzheimer's disease (AD). Lobar and subcortical volumes were measured using FreeSurfer from MRI data of 1,686 normal Koreans (age range 59-89) and 851 Caucasian, non-Hispanic subjects in the ADNI and OASIS datasets. The regression models were designed to predict brain volumes, including ethnicity, age, sex, intracranial volume (ICV), magnetic field strength (MFS), and MRI scanner manufacturers as independent variables. Ethnicity had a significant effect for all lobar (vertical bar beta vertical bar > 0.20, p < 0.001) and subcortical regions (vertical bar beta vertical bar > 0.08, p < 0.001) except left pallidus and bilateral ventricles. To demonstrate the validity of the z-score for AD diagnosis, 420 patients and 420 normal controls were selected evenly from the Korean and Caucasian datasets. The four validation groups divided by race and diagnosis were matched on age and sex using a propensity score matching. We analyzed whether and to what extent the ethnicity adjustment improved the diagnostic power of the logistic regression model that was built using the only z-scores of six regions: bilateral temporal cortices, hippocampi, and amygdalae. The performance of the classifier after ethnicity adjustment was significantly improved compared with the classifier before ethnicity adjustment (Delta AUC = 0.10, D = 7.80, p < 0.001; AUC comparison test using bootstrap). Korean AD dementia patients may not be classified by Caucasian norms of brain volumes because the brain regions vulnerable to AD dementia are bigger in normal Korean elderly peoples. Therefore, ethnicity is an essential factor in establishing normative data for regional volumes in brain aging and applying it to the diagnosis of neurodegenerative diseases.-
dc.language영어-
dc.language.isoen-
dc.publisherFRONTIERS MEDIA SA-
dc.titleMulti-Racial Normative Data for Lobar and Subcortical Brain Volumes in Old Age: Korean and Caucasian Norms May Be Incompatible With Each Other-
dc.typeArticle-
dc.contributor.affiliatedAuthorChoe, Youngshik-
dc.identifier.doi10.3389/fnagi.2021.675016-
dc.identifier.wosid000685495200001-
dc.identifier.bibliographicCitationFRONTIERS IN AGING NEUROSCIENCE, v.13-
dc.relation.isPartOfFRONTIERS IN AGING NEUROSCIENCE-
dc.citation.titleFRONTIERS IN AGING NEUROSCIENCE-
dc.citation.volume13-
dc.type.rimsART-
dc.type.docTypeArticle-
dc.description.journalClass1-
dc.description.isOpenAccessN-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.relation.journalResearchAreaGeriatrics & Gerontology-
dc.relation.journalResearchAreaNeurosciences & Neurology-
dc.relation.journalWebOfScienceCategoryGeriatrics & Gerontology-
dc.relation.journalWebOfScienceCategoryNeurosciences-
dc.subject.keywordPlusSURFACE-BASED ANALYSIS-
dc.subject.keywordPlusHUMAN CEREBRAL-CORTEX-
dc.subject.keywordPlusSEGMENTATION-
dc.subject.keywordPlusMORPHOLOGY-
dc.subject.keywordPlusTHICKNESS-
dc.subject.keywordPlusLIFETIME-
dc.subject.keywordPlusDISEASE-
dc.subject.keywordPlusREGIONS-
dc.subject.keywordPlusATROPHY-
dc.subject.keywordPlusSYSTEM-
dc.subject.keywordAuthoraging-
dc.subject.keywordAuthornorm-
dc.subject.keywordAuthorethnic difference-
dc.subject.keywordAuthorAlzheimer&apos-
dc.subject.keywordAuthors disease-
dc.subject.keywordAuthorbrain magnetic resonance imaging-
Files in This Item
There are no files associated with this item.
Appears in
Collections
연구본부 > 뇌발달질환 연구그룹 > 1. Journal Articles

qrcode

Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.

Related Researcher

Researcher Choe, Youngshik photo

Choe, Youngshik
연구본부 (뇌발달질환 연구그룹)
Read more

Altmetrics

Total Views & Downloads

BROWSE