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The adverse effects of selenomethionine on skeletal muscle, liver, and brain in the steelhead trout (Oncorhynchus mykiss)

Authors
Lee, Jang-WonDeng, Dong-FangLee, JinsuKim, KiyoungJung, Hyun JinChoe, YoungshikPark, Seung HwaYoon, Minjung
Issue Date
Nov-2020
Publisher
ELSEVIER
Keywords
Selenium neurotoxicity; Steelhead trout; Neuromuscular system; Histopathology; Oxidative stress
Citation
ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY, v.80
Journal Title
ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
Volume
80
URI
http://scholarworks.bwise.kr/kbri/handle/2023.sw.kbri/568
DOI
10.1016/j.etap.2020.103451
ISSN
1382-6689
Abstract
Juvenile Oncorhynchus mykiss (average weight 22.3 g) were fed one of five selenomethionine diets (1.09, 8.79, 15.37, 30.79, or 61.58 mg Se/kg diet). After 4 weeks, hepatic catalase activity over 15.37 mg Se/kg diets was significantly decreased, and the glutathione peroxidase activity over 30.79 mg Se/kg diets was elevated compared to the controls. In the brain, the dopamine levels at 61.58 mg Se/kg diet and the serotonin levels over 15.37 mg Se/kg diets were significantly increased, whereas the 3,4-dihydroxyphenylacetic acid, homovanillic acid, and dopamine turnover, and the 5-hydroxyindoleacetic acid and serotonin turnover over 30.79 mg Se/kg diets were decreased. In muscle, the 3-nitrotyrosine level over 15.37 mg Se/kg diets, acetylcholine esterase activity over 30.79 mg Se/kg diets, and histological alterations over 8.79 mg Se/kg diets were increased. Our current results showed that selenomethionine disrupted dopamine and serotonin metabolism in the brain and damaged the neuromuscular system in skeletal muscle.
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