Detailed Information

Cited 6 time in webofscience Cited 7 time in scopus
Metadata Downloads

The MAO Inhibitor Tranylcypromine Alters LPS- and A beta-Mediated Neuroinflammatory Responses in Wild-type Mice and a Mouse Model of AD

Authors
Park, HyunHeeHan, Kyung-MinJeon, HyongjunLee, Ji-SooLee, HyunjuJeon, Seong GakPark, Jin-HeeKim, Yu GyungLin, YuxiLee, Young-HoJeong, Yun HaHoe, Hyang-Sook
Issue Date
Sep-2020
Publisher
MDPI
Keywords
neuroinflammation; MAO inhibitor; microglia; amyloid beta; LPS
Citation
CELLS, v.9, no.9
Journal Title
CELLS
Volume
9
Number
9
URI
http://scholarworks.bwise.kr/kbri/handle/2023.sw.kbri/589
DOI
10.3390/cells9091982
ISSN
2073-4409
Abstract
Monoamine oxidase (MAO) has been implicated in neuroinflammation, and therapies targeting MAO are of interest for neurodegenerative diseases. The small-molecule drug tranylcypromine, an inhibitor of MAO, is currently used as an antidepressant and in the treatment of cancer. However, whether tranylcypromine can regulate LPS- and/or A beta-induced neuroinflammation in the brain has not been well-studied. In the present study, we found that tranylcypromine selectively altered LPS-induced proinflammatory cytokine levels in BV2 microglial cells but not primary astrocytes. In addition, tranylcypromine modulated LPS-mediated TLR4/ERK/STAT3 signaling to alter neuroinflammatory responses in BV2 microglial cells. Importantly, tranylcypromine significantly reduced microglial activation as well as proinflammatory cytokine levels in LPS-injected wild-type mice. Moreover, injection of tranylcypromine in 5xFAD mice (a mouse model of AD) significantly decreased microglial activation but had smaller effects on astrocyte activation. Taken together, our results suggest that tranylcypromine can suppress LPS- and A beta-induced neuroinflammatory responses in vitro and in vivo.
Files in This Item
There are no files associated with this item.
Appears in
Collections
연구본부 > 퇴행성 뇌질환 연구그룹 > 1. Journal Articles

qrcode

Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.

Related Researcher

Researcher Jeong, Yun Ha photo

Jeong, Yun Ha
연구본부 (퇴행성뇌질환 연구그룹)
Read more

Altmetrics

Total Views & Downloads

BROWSE