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Metformin Alleviates Left Ventricular Diastolic Dysfunction in a Rat Myocardial Ischemia Reperfusion Injury Model

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dc.contributor.authorJo Woori-
dc.contributor.authorKang Kyung-Ku-
dc.contributor.authorChae Sehyun-
dc.contributor.authorSon Woo-Chan-
dc.date.accessioned2023-08-16T09:48:25Z-
dc.date.available2023-08-16T09:48:25Z-
dc.date.created2022-05-24-
dc.date.issued2020-02-
dc.identifier.issn1661-6596-
dc.identifier.urihttp://scholarworks.bwise.kr/kbri/handle/2023.sw.kbri/638-
dc.description.abstractAn increased incidence of myocardial infarction (MI) has recently emerged as the cause of cardiovascular morbidity and mortality worldwide. In this study, cardiac function was investigated in a rat myocardial ischemia/reperfusion (I/R) model using echocardiography. Metformin administration significantly increased ejection fraction and fractional shortening values on Days 3 and 7 when MI occurred, indicating that metformin improved left ventricular systolic function. In the Sham + MET and MI + MET groups, the E' value was significantly different up to Day 3 but not at Day 7. This may mean that left ventricular diastolic function was effectively restored to some extent by Day 7 when metformin was administered. These results suggest that diastolic dysfunction, assessed by echocardiography, does not recover in the early phase of ischemic reperfusion injury in the rat myocardial I/R model. However, administering metformin resulted in recovery in the early phase of ischemic reperfusion injury in this model. Further gene expression profiling of left ventricle tissues revealed that the metformin-treated group had notably attenuated immune and inflammatory profiles. To sum up, a rat myocardial I/R injury model and ultrasound-based assessment of left ventricular systolic and diastolic function can be used in translational research and for the development of new heart failure-related drugs, in addition to evaluating the potential of metformin to improve left ventricular (LV) diastolic function.-
dc.publisherMultidisciplinary Digital Publishing Institute (MDPI)-
dc.titleMetformin Alleviates Left Ventricular Diastolic Dysfunction in a Rat Myocardial Ischemia Reperfusion Injury Model-
dc.typeArticle-
dc.contributor.affiliatedAuthorChae Sehyun-
dc.identifier.wosid000522524400316-
dc.identifier.bibliographicCitationInternational Journal of Molecular Sciences, v.21, no.4-
dc.relation.isPartOfInternational Journal of Molecular Sciences-
dc.citation.titleInternational Journal of Molecular Sciences-
dc.citation.volume21-
dc.citation.number4-
dc.type.rimsART-
dc.description.journalClass1-
dc.description.isOpenAccessY-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
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