Detailed Information

Cited 12 time in webofscience Cited 15 time in scopus
Metadata Downloads

Deletion of PLC gamma 1 in GABAergic neurons increases seizure susceptibility in aged mice

Authors
Kim, Hye YunYang, Yong RyoulHwang, HongikLee, Ha-EunJang, Hyun-JunKim, JeongyeonYang, EstherKim, HyunRhim, HyewhonSuh, Pann-GhillKim, Jae-Ick
Issue Date
Nov-2019
Publisher
NATURE PORTFOLIO
Citation
SCIENTIFIC REPORTS, v.9
Journal Title
SCIENTIFIC REPORTS
Volume
9
URI
http://scholarworks.bwise.kr/kbri/handle/2023.sw.kbri/664
DOI
10.1038/s41598-019-54477-4
ISSN
2045-2322
Abstract
Synaptic inhibition plays a fundamental role in the information processing of neural circuits. It sculpts excitatory signals and prevents hyperexcitability of neurons. Owing to these essential functions, dysregulated synaptic inhibition causes a plethora of neurological disorders, including epilepsy, autism, and schizophrenia. Among these disorders, epilepsy is associated with abnormal hyperexcitability of neurons caused by the deficits of GABAergic neuron or decreased GABAergic inhibition at synapses. Although many antiepileptic drugs are intended to improve GABA-mediated inhibition, the molecular mechanisms of synaptic inhibition regulated by GABAergic neurons are not fully understood. Increasing evidence indicates that phospholipase C gamma 1 (PLC gamma 1) is involved in the generation of seizure, while the causal relationship between PLC gamma 1 and seizure has not been firmly established yet. Here, we show that genetic deletion of PLC gamma 1 in GABAergic neurons leads to handling-induced seizure in aged mice. In addition, aged Plcg1(F/F); Dlx5/6-Cre mice exhibit other behavioral alterations, including hypoactivity, reduced anxiety, and fear memory deficit. Notably, inhibitory synaptic transmission as well as the number of inhibitory synapses are decreased in the subregions of hippocampus. These findings suggest that PLC gamma 1 may be a key determinant of maintaining both inhibitory synapses and synaptic transmission, potentially contributing to the regulation of E/I balance in the hippocampus.
Files in This Item
There are no files associated with this item.
Appears in
Collections
연구본부 > 정서·인지 질환 연구그룹 > 1. Journal Articles

qrcode

Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.

Related Researcher

Researcher Kim, Jeong yeon photo

Kim, Jeong yeon
연구본부 (정서·인지질환 연구그룹)
Read more

Altmetrics

Total Views & Downloads

BROWSE