Detailed Information

Cited 10 time in webofscience Cited 12 time in scopus
Metadata Downloads

Safety and efficacy of a metal stent covered with a silicone membrane containing integrated silver particles in preventing biofilm and sludge formation in endoscopic drainage of malignant biliary obstruction: a phase 2 pilot study

Full metadata record
DC Field Value Language
dc.contributor.authorLee, Tae Hoon-
dc.contributor.authorJung, Min Kyo-
dc.contributor.authorKim, Tae-Keun-
dc.contributor.authorPack, Chan Gi-
dc.contributor.authorPark, Yoon Kyung-
dc.contributor.authorKim, Seon-Ok-
dc.contributor.authorPark, Do Hyun-
dc.date.accessioned2023-08-16T09:48:30Z-
dc.date.available2023-08-16T09:48:30Z-
dc.date.created2022-01-13-
dc.date.issued2019-10-
dc.identifier.issn0016-5107-
dc.identifier.urihttp://scholarworks.bwise.kr/kbri/handle/2023.sw.kbri/666-
dc.description.abstractBackground and Aims: Membrane-covered self-expandable metal stents (SEMSs) have been developed to prolong the patency of stents by reducing tissue hyperplasia or tumor ingrowth. However, their effectiveness is attenuated by stent clogging as a result of biofilm formation on the inner surface of the membrane. The aim of this pilot study was to evaluate the efficacy and safety of SEMSs covered with a silicone membrane containing integrated silver particles (Ag-P) in malignant distal biliary obstruction. Methods: Twenty-four patients who underwent SEMS placement because of malignant distal biliary obstruction were enrolled in this single-center pilot study. The main outcomes were technical success, clinical success, adverse events, stent patency, and survival. Results: The technical and clinical success rates were 100% and 91.7% (22 of 24), respectively. The rates of early and late adverse events were 22.7% and 36.4%, respectively. The primary reintervention rate was 27.3% (6 of 22). Only 1 case involving stent malfunction was associated with sludge impaction. Median stent patency was 179 days. During follow-up, there were no serious adverse events or mortality related to the stents or Ag-P. Serum and urine silver concentrations before and after stent placement and at 32 weeks after placement did not differ. All serum and urine silver concentrations were <3 mu g/L (3 ppb) and 5 mu g/L (5 ppb), respectively. Conclusions: SEMSs covered with a silicone membrane containing integrated Ag-Ps may be effective and safe in malignant distal biliary obstruction. Stent dysfunction related to sludge impaction may be less frequent using this new stent.-
dc.language영어-
dc.language.isoen-
dc.publisherMOSBY-ELSEVIER-
dc.titleSafety and efficacy of a metal stent covered with a silicone membrane containing integrated silver particles in preventing biofilm and sludge formation in endoscopic drainage of malignant biliary obstruction: a phase 2 pilot study-
dc.typeArticle-
dc.contributor.affiliatedAuthorJung, Min Kyo-
dc.identifier.doi10.1016/j.gie.2019.06.007-
dc.identifier.scopusid2-s2.0-85069916135-
dc.identifier.wosid000486385600018-
dc.identifier.bibliographicCitationGASTROINTESTINAL ENDOSCOPY, v.90, no.4, pp.663 - +-
dc.relation.isPartOfGASTROINTESTINAL ENDOSCOPY-
dc.citation.titleGASTROINTESTINAL ENDOSCOPY-
dc.citation.volume90-
dc.citation.number4-
dc.citation.startPage663-
dc.citation.endPage+-
dc.type.rimsART-
dc.type.docTypeArticle-
dc.description.journalClass1-
dc.description.isOpenAccessN-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.relation.journalResearchAreaGastroenterology & Hepatology-
dc.relation.journalWebOfScienceCategoryGastroenterology & Hepatology-
dc.subject.keywordPlusIN-VITRO EVALUATION-
dc.subject.keywordPlusBACTERIAL BIOFILM-
dc.subject.keywordPlusNANOPARTICLES-
dc.subject.keywordPlusMULTICENTER-
dc.subject.keywordPlusPALLIATION-
dc.subject.keywordPlusSTRICTURES-
dc.subject.keywordPlusMIGRATION-
dc.subject.keywordPlusBLOCKAGE-
dc.subject.keywordPlusPATENCY-
Files in This Item
There are no files associated with this item.
Appears in
Collections
연구본부 > 신경회로 연구그룹 > 1. Journal Articles

qrcode

Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.

Related Researcher

Researcher Jung, Min kyo photo

Jung, Min kyo
연구본부 (신경회로 연구그룹)
Read more

Altmetrics

Total Views & Downloads

BROWSE