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Cited 11 time in webofscience Cited 12 time in scopus
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Vaccinia-related kinase 2 plays a critical role in microglia-mediated synapse elimination during neurodevelopment

Authors
Lee, JuhyunLee, SeunghyunRyu, Young-JaeLee, DohyunKim, SangjuneSeo, Ji-YoungOh, EunjiPaek, Sun HaKim, Seung U.Ha, Chang-ManChoi, Se-YoungKim, Kyong-Tai
Issue Date
Sep-2019
Publisher
WILEY
Keywords
microglia; neurodevelopment; synapse elimination; VRK2
Citation
GLIA, v.67, no.9, pp.1667 - 1679
Journal Title
GLIA
Volume
67
Number
9
Start Page
1667
End Page
1679
URI
http://scholarworks.bwise.kr/kbri/handle/2023.sw.kbri/671
DOI
10.1002/glia.23638
ISSN
0894-1491
Abstract
During postnatal neurodevelopment, excessive synapses must be eliminated by microglia to complete the establishment of neural circuits in the brain. The lack of synaptic regulation by microglia has been implicated in neurodevelopmental disorders such as autism, schizophrenia, and intellectual disability. Here we suggest that vaccinia-related kinase 2 (VRK2), which is expressed in microglia, may stimulate synaptic elimination by microglia. In VRK2-deficient mice (VRK2(KO)), reduced numbers of presynaptic puncta within microglia were observed. Moreover, the numbers of presynaptic puncta and synapses were abnormally increased in VRK2(KO) mice by the second postnatal week. These differences did not persist into adulthood. Even though an increase in the number of synapses was normalized, adult VRK2(KO) mice showed behavioral defects in social behaviors, contextual fear memory, and spatial memory.
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연구전략실 (첨단뇌연구장비센터)
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