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Cited 41 time in webofscience Cited 44 time in scopus
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MDT-15/MED15 permits longevity at low temperature via enhancing lipidostasis and proteostasis

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dc.contributor.authorLee, Dongyeop-
dc.contributor.authorAn, Seon Woo A.-
dc.contributor.authorJung, Yoonji-
dc.contributor.authorYamaoka, Yasuyo-
dc.contributor.authorRyu, Youngjae-
dc.contributor.authorGoh, Grace Ying Shyen-
dc.contributor.authorBeigi, Arshia-
dc.contributor.authorYang, Jae-Seong-
dc.contributor.authorJung, Gyoo Yeol-
dc.contributor.authorMa, Dengke K.-
dc.contributor.authorHa, Chang Man-
dc.contributor.authorTaubert, Stefan-
dc.contributor.authorLee, Youngsook-
dc.contributor.authorLee, Seung-Jae, V-
dc.date.accessioned2023-08-16T09:48:31Z-
dc.date.available2023-08-16T09:48:31Z-
dc.date.created2022-01-11-
dc.date.issued2019-08-
dc.identifier.issn1544-9173-
dc.identifier.urihttp://scholarworks.bwise.kr/kbri/handle/2023.sw.kbri/675-
dc.description.abstractLow temperatures delay aging and promote longevity in many organisms. However, the metabolic and homeostatic aspects of low-temperature-induced longevity remain poorly understood. Here, we show that lipid homeostasis regulated by Caenorhabditis elegans Mediator 15 (MDT-15 or MED15), a transcriptional coregulator, is essential for low-temperature-induced longevity and proteostasis. We find that inhibition of mdt-15 prevents animals from living long at low temperatures. We show that MDT-15 up-regulates fat-7, a fatty acid desaturase that converts saturated fatty acids (SFAs) to unsaturated fatty acids (UFAs), at low temperatures. We then demonstrate that maintaining a high UFA/SFA ratio is essential for proteostasis at low temperatures. We show that dietary supplementation with a monounsaturated fatty acid, oleic acid (OA), substantially mitigates the short life span and proteotoxicity in mdt-15(-) animals at low temperatures. Thus, lipidostasis regulated by MDT-15 appears to be a limiting factor for proteostasis and longevity at low temperatures. Our findings highlight the crucial roles of lipid regulation in maintaining normal organismal physiology under different environmental conditions.-
dc.language영어-
dc.language.isoen-
dc.publisherPUBLIC LIBRARY SCIENCE-
dc.titleMDT-15/MED15 permits longevity at low temperature via enhancing lipidostasis and proteostasis-
dc.typeArticle-
dc.contributor.affiliatedAuthorRyu, Youngjae-
dc.contributor.affiliatedAuthorMa, Dengke K.-
dc.identifier.doi10.1371/journal.pbio.3000415-
dc.identifier.scopusid2-s2.0-85071281609-
dc.identifier.wosid000483408500030-
dc.identifier.bibliographicCitationPLOS BIOLOGY, v.17, no.8-
dc.relation.isPartOfPLOS BIOLOGY-
dc.citation.titlePLOS BIOLOGY-
dc.citation.volume17-
dc.citation.number8-
dc.type.rimsART-
dc.type.docTypeArticle-
dc.description.journalClass1-
dc.description.isOpenAccessN-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.relation.journalResearchAreaBiochemistry & Molecular Biology-
dc.relation.journalResearchAreaLife Sciences & Biomedicine - Other Topics-
dc.relation.journalWebOfScienceCategoryBiochemistry & Molecular Biology-
dc.relation.journalWebOfScienceCategoryBiology-
dc.subject.keywordPlusFATTY-ACID-COMPOSITION-
dc.subject.keywordPlusC. ELEGANS-
dc.subject.keywordPlusLIFE-SPAN-
dc.subject.keywordPlusCAENORHABDITIS-ELEGANS-
dc.subject.keywordPlusEXPRESSION ANALYSIS-
dc.subject.keywordPlusMEDIATOR SUBUNIT-
dc.subject.keywordPlusSTRESS-
dc.subject.keywordPlusMETABOLISM-
dc.subject.keywordPlusACTIVATION-
dc.subject.keywordPlusINHIBITION-
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연구전략실 > 첨단뇌연구장비센터 > 1. Journal Articles

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연구전략실 (첨단뇌연구장비센터)
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