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Cited 16 time in webofscience Cited 15 time in scopus
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Structure-Activity Relationships of Baicalein and its Analogs as Novel TSLP Inhibitors

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dc.contributor.authorBernie Byunghoon Park-
dc.contributor.authorJae Wan Choi-
dc.contributor.authorDawon Park-
dc.contributor.authorDoyoung Choi-
dc.contributor.authorJiwon Paek-
dc.contributor.author김현정-
dc.contributor.authorSe-Young Son-
dc.contributor.authorAmeeq Ul Mushtaq-
dc.contributor.authorHyeji Shin-
dc.contributor.authorSang Hoon Kim-
dc.contributor.authorYuanyuan Zhou-
dc.contributor.authorTaehyeong Lim-
dc.contributor.authorJi Young Park-
dc.contributor.authorJi-Young Baek-
dc.contributor.authorKyul Kim-
dc.contributor.authorHongmok Kwon-
dc.contributor.authorSang-Hyun Son-
dc.contributor.authorKa Young Chung-
dc.contributor.authorHyun-Ja Jeong-
dc.contributor.authorHyung-Min Kim-
dc.contributor.authorYong Woo Jung-
dc.contributor.authorKiho Lee-
dc.contributor.authorKi Yong Lee-
dc.contributor.authorYoungjoo Byun-
dc.contributor.authorYoung Ho Jeon-
dc.date.accessioned2023-08-16T09:48:33Z-
dc.date.available2023-08-16T09:48:33Z-
dc.date.created2022-05-24-
dc.date.issued2019-06-
dc.identifier.issn2045-2322-
dc.identifier.urihttp://scholarworks.bwise.kr/kbri/handle/2023.sw.kbri/687-
dc.description.abstractThymic stromal lymphopoietin (TSLP) plays an important role in the differentiation and proliferation of Th2 cells, resulting in eosinophilic inflammation and numerous allergic diseases. Baicalein (1), a major component of Scutellaria baicalensis, was found to be the first small molecule to block TSLP signaling pathways. It inhibited effectively eosinophil infiltration in house dust mite-induced and ovalbumin-challenged mouse models. Structure-activity relationship studies identified compound 11a, a biphenyl flavanone analog, as a novel human TSLP inhibitor for the discovery and development of new anti-allergic drugs.-
dc.publisherNature Publishing Group-
dc.titleStructure-Activity Relationships of Baicalein and its Analogs as Novel TSLP Inhibitors-
dc.typeArticle-
dc.contributor.affiliatedAuthor김현정-
dc.identifier.doi10.1038/s41598-019-44853-5-
dc.identifier.scopusid2-s2.0-85068401290-
dc.identifier.wosid000472029100041-
dc.identifier.bibliographicCitationScientific Reports, v.9, no.1-
dc.relation.isPartOfScientific Reports-
dc.citation.titleScientific Reports-
dc.citation.volume9-
dc.citation.number1-
dc.type.rimsART-
dc.description.journalClass1-
dc.description.isOpenAccessN-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.relation.journalResearchAreaScience & Technology - Other Topics-
dc.relation.journalWebOfScienceCategoryMultidisciplinary Sciences-
dc.subject.keywordPlusTHYMIC STROMAL LYMPHOPOIETIN-
dc.subject.keywordPlusINNATE LYMPHOID-CELLS-
dc.subject.keywordPlusBIOLOGICAL EVALUATION-
dc.subject.keywordPlusTYPE-2 IMMUNITY-
dc.subject.keywordPlusDERIVATIVES-
dc.subject.keywordPlusFLAVONOIDS-
dc.subject.keywordPlusCYTOKINE-
dc.subject.keywordPlusBINDING-
dc.subject.keywordPlusINFLAMMATION-
dc.subject.keywordPlusCHALCONES-
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