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NOTUM Is Involved in the Progression of Colorectal Cancer

Authors
Yoon, Jong HyukKim, DayeaKim, JaeyoonLee, HyeongjooGhim, JaewangKang, Byung JunSong, ParkyongSuh, Pann-GhillRyu, Sung HoLee, Taehoon G.
Issue Date
Nov-2018
Publisher
INT INST ANTICANCER RESEARCH
Keywords
NOTUM; secretomics; colorectal cancer; migration; diagnosis
Citation
CANCER GENOMICS & PROTEOMICS, v.15, no.6, pp.485 - 497
Journal Title
CANCER GENOMICS & PROTEOMICS
Volume
15
Number
6
Start Page
485
End Page
497
URI
http://scholarworks.bwise.kr/kbri/handle/2023.sw.kbri/718
DOI
10.21873/cgp.20107
ISSN
1109-6535
Abstract
Background: There are limitations to current colorectal cancer (CRC)-specific diagnostic methods and therapies. Tumorigenesis proceeds because of interaction between cancer cells and various surrounding cells; discovering new molecular mediators through studies of the CRC secretome is a promising approach for the development of CRC diagnostics and therapies. Materials and Methods: A comparative secretomic analysis was performed using primary and metastatic human isogenic CRC cells. Proliferation was determined by MTT and thymidine incorporation assay, migration was determined by wound-healing assay (ELISA). The level of palmitoleoyl-protein carboxylesterase (NOTUM) in plasma from patients with CRC was determined by enzyme-linked immunosorbent assay. Results: NOTUM expression was increased in metastatic cells. Proliferation was suppressed by inhibiting expression of NOTUM. Knockdown of NOTUM genes inhibited proliferation as well as migration, with possible involvement of p38 and c-JUN N-terminal kinase in this process. The result was verified in patients with CRC. Conclusion: NOTUM may be a new candidate for diagnostics and therapy of CRC.
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연구본부 (퇴행성 뇌질환 연구그룹)
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