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Vesicular glutamate transporter 1 (VGLUT1)- and VGLUT2-immunopositive axon terminals on the rat jaw-closing and jaw-opening motoneurons

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dc.contributor.authorPark, Sook Kyung-
dc.contributor.authorKo, Sang Jin-
dc.contributor.authorPaik, Sang Kyoo-
dc.contributor.authorRah, Jong-Cheol-
dc.contributor.authorLee, Kea Joo-
dc.contributor.authorBae, Yong Chul-
dc.date.accessioned2023-08-16T09:49:39Z-
dc.date.available2023-08-16T09:49:39Z-
dc.date.created2022-01-13-
dc.date.issued2018-06-
dc.identifier.issn1863-2653-
dc.identifier.urihttp://scholarworks.bwise.kr/kbri/handle/2023.sw.kbri/736-
dc.description.abstractTo provide information on the glutamatergic synapses on the trigeminal motoneurons, which may be important for understanding the mechanism of control of jaw movements, we investigated the distribution of vesicular glutamate transporter (VGLUT)1-immunopositive (+) and VGLUT2+ axon terminals (boutons) on the rat jaw-closing (JC) and jaw-opening (JO) motoneurons, and their morphological determinants of synaptic strength by retrograde tracing, electron microscopic immunohistochemistry, and quantitative ultrastructural analysis. We found that (1) the large majority of VGLUT + boutons on JC and JO motoneurons were VGLUT2+, (2) the density of VGLUT1 + boutons terminating on JC motoneurons was significantly higher than that on JO motoneurons, (3) the density of VGLUT1 + boutons terminating on non-primary dendrites of JC motoneurons was significantly higher than that on somata or primary dendrites, whereas the density of VGLUT2 + boutons was not significantly different between JC and JO motoneurons and among various compartments of the postsynaptic neurons, and (4) the bouton volume, mitochondrial volume, and active zone area of the VGLUT1 + boutons forming synapses on JC motoneurons were significantly bigger than those of VGLUT2 + boutons. These findings suggest that JC and JO motoneurons receive glutamatergic input primarily from VGLUT2-expressing intrinsic neurons (premotoneurons), and may be controlled differently by neurons in the trigeminal mesencephalic nucleus and by glutamatergic premotoneurons.-
dc.language영어-
dc.language.isoen-
dc.publisherSPRINGER HEIDELBERG-
dc.titleVesicular glutamate transporter 1 (VGLUT1)- and VGLUT2-immunopositive axon terminals on the rat jaw-closing and jaw-opening motoneurons-
dc.typeArticle-
dc.contributor.affiliatedAuthorRah, Jong-Cheol-
dc.contributor.affiliatedAuthorLee, Kea Joo-
dc.identifier.doi10.1007/s00429-018-1636-y-
dc.identifier.scopusid2-s2.0-85045027614-
dc.identifier.wosid000433110800017-
dc.identifier.bibliographicCitationBRAIN STRUCTURE & FUNCTION, v.223, no.5, pp.2323 - 2334-
dc.relation.isPartOfBRAIN STRUCTURE & FUNCTION-
dc.citation.titleBRAIN STRUCTURE & FUNCTION-
dc.citation.volume223-
dc.citation.number5-
dc.citation.startPage2323-
dc.citation.endPage2334-
dc.type.rimsART-
dc.type.docTypeArticle-
dc.description.journalClass1-
dc.description.isOpenAccessN-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.relation.journalResearchAreaAnatomy & Morphology-
dc.relation.journalResearchAreaNeurosciences & Neurology-
dc.relation.journalWebOfScienceCategoryAnatomy & Morphology-
dc.relation.journalWebOfScienceCategoryNeurosciences-
dc.subject.keywordPlusTRIGEMINAL SENSORY NUCLEI-
dc.subject.keywordPlusMUSCLE-SPINDLE AFFERENTS-
dc.subject.keywordPlusDORSAL-ROOT GANGLIA-
dc.subject.keywordPlusSPINAL-CORD-
dc.subject.keywordPlusCENTRAL SYNAPSE-
dc.subject.keywordPlusMOTOR NUCLEUS-
dc.subject.keywordPlusVGLUT1-
dc.subject.keywordPlusNEURONS-
dc.subject.keywordPlusORGANIZATION-
dc.subject.keywordPlusEXPRESSION-
dc.subject.keywordAuthorVesicular glutamate transporter-
dc.subject.keywordAuthorGlutamatergic synapse-
dc.subject.keywordAuthorJaw-closing motoneuron-
dc.subject.keywordAuthorJaw-opening motoneuron-
dc.subject.keywordAuthorImmunohistochemistry-
dc.subject.keywordAuthorElectron microscopy-
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연구본부 > 감각·운동시스템 연구그룹 > 1. Journal Articles
연구본부 > 신경회로 연구그룹 > 1. Journal Articles

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