Detailed Information

Cited 78 time in webofscience Cited 80 time in scopus
Metadata Downloads

Microglial transglutaminase-2 drives myelination and myelin repair via GPR56/ADGRG1 in oligodendrocyte precursor cells

Full metadata record
DC Field Value Language
dc.contributor.authorGiera, Stefanie-
dc.contributor.authorLuo, Rong-
dc.contributor.authorYing, Yanqin-
dc.contributor.authorAckerman, Sarah D.-
dc.contributor.authorJeong, Sung-Jin-
dc.contributor.authorStoveken, Hannah M.-
dc.contributor.authorFolts, Christopher J.-
dc.contributor.authorWelsh, Christina A.-
dc.contributor.authorTall, Gregory G.-
dc.contributor.authorStevens, Beth-
dc.contributor.authorMonk, Kelly R.-
dc.contributor.authorPiao, Xianhua-
dc.date.accessioned2023-08-16T09:49:40Z-
dc.date.available2023-08-16T09:49:40Z-
dc.date.created2022-01-13-
dc.date.issued2018-05-
dc.identifier.issn2050-084X-
dc.identifier.urihttp://scholarworks.bwise.kr/kbri/handle/2023.sw.kbri/741-
dc.description.abstractIn the central nervous system (CNS), myelin formation and repair are regulated by oligodendrocyte (OL) lineage cells, which sense and integrate signals from their environment, including from other glial cells and the extracellular matrix (ECM). The signaling pathways that coordinate this complex communication, however, remain poorly understood. The adhesion G protein-coupled receptor ADGRG1 (also known as GPR56) is an evolutionarily conserved regulator of OL development in humans, mice, and zebrafish, although its activating ligand for OL lineage cells is unknown. Here, we report that microglia-derived transglutaminase-2 (TG2) signals to ADGRG1 on OL precursor cells (OPCs) in the presence of the ECM protein laminin and that TG2/laminin-dependent activation of ADGRG1 promotes OPC proliferation. Signaling by TG2/laminin to ADGRG1 on OPCs additionally improves remyelination in two murine models of demyelination. These findings identify a novel glia-to-glia signaling pathway that promotes myelin formation and repair, and suggest new strategies to enhance remyelination.-
dc.language영어-
dc.language.isoen-
dc.publisherELIFE SCIENCES PUBLICATIONS LTD-
dc.titleMicroglial transglutaminase-2 drives myelination and myelin repair via GPR56/ADGRG1 in oligodendrocyte precursor cells-
dc.typeArticle-
dc.contributor.affiliatedAuthorJeong, Sung-Jin-
dc.identifier.doi10.7554/eLife.33385-
dc.identifier.scopusid2-s2.0-85051957875-
dc.identifier.wosid000433540200001-
dc.identifier.bibliographicCitationELIFE, v.7-
dc.relation.isPartOfELIFE-
dc.citation.titleELIFE-
dc.citation.volume7-
dc.type.rimsART-
dc.type.docTypeArticle-
dc.description.journalClass1-
dc.description.isOpenAccessN-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.relation.journalResearchAreaLife Sciences & Biomedicine - Other Topics-
dc.relation.journalWebOfScienceCategoryBiology-
dc.subject.keywordPlusPROTEIN-COUPLED RECEPTOR-
dc.subject.keywordPlusNERVOUS-SYSTEM-
dc.subject.keywordPlusTISSUE TRANSGLUTAMINASE-
dc.subject.keywordPlusCROSS-LINKING-
dc.subject.keywordPlusDIFFERENTIATION-
dc.subject.keywordPlusMACROPHAGES-
dc.subject.keywordPlusZEBRAFISH-
dc.subject.keywordPlusDISTINCT-
dc.subject.keywordPlusGROWTH-
dc.subject.keywordPlusGPR56-
Files in This Item
There are no files associated with this item.
Appears in
Collections
연구본부 > 뇌발달질환 연구그룹 > 1. Journal Articles

qrcode

Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.

Related Researcher

Researcher Jeong, Sung Jin photo

Jeong, Sung Jin
연구본부 (뇌발달질환 연구그룹)
Read more

Altmetrics

Total Views & Downloads

BROWSE