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Cited 3 time in webofscience Cited 1 time in scopus
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Image-guided recording system for spatial and temporal mapping of neuronal activities in brain slice

Authors
Choi, GeonhoLee, JeonghyeonKim, HyeongeunJang, JaemyungIm, ChangkyunJeon, NooliJung, Woonggyu
Issue Date
Mar-2018
Publisher
WILEY-V C H VERLAG GMBH
Keywords
brain slice; image-guided recording system; microelectrode array; neuronal signal mapping; optical coherence tomography
Citation
JOURNAL OF BIOPHOTONICS, v.11, no.3
Journal Title
JOURNAL OF BIOPHOTONICS
Volume
11
Number
3
URI
http://scholarworks.bwise.kr/kbri/handle/2023.sw.kbri/749
DOI
10.1002/jbio.201700243
ISSN
1864-063X
Abstract
In this study, we introduce the novel image-guided recording system (IGRS) for efficient interpretation of neuronal activities in the brain slice. IGRS is designed to combine microelectrode array (MEA) and optical coherence tomography at the customized upright microscope. It allows to record multi-site neuronal signals and image of the volumetric brain anatomy in a single body configuration. For convenient interconnection between a brain image and neuronal signals, we developed the automatic mapping protocol that enables us to project acquired neuronal signals on a brain image. To evaluate the performance of IGRS, hippocampal signals of the brain slice were monitored, and corresponding with two-dimensional neuronal maps were successfully reconstructed. Our results indicated that IGRS and mapping protocol can provide the intuitive information regarding long-term and multi-sites neuronal signals. In particular, the temporal and spatial mapping capability of neuronal signals would be a very promising tool to observe and analyze the massive neuronal activity and connectivity in MEA-based electrophysiological studies.
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연구본부 (뇌발달질환 연구그룹)
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