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Epimedium koreanum Nakai inhibits PMA-induced cancer cell migration and invasion by modulating NF-kappa B/MMP-9 signaling in monomorphic malignant human glioma cells

Authors
Lee, WonilNam, Jin HanCho, Hyun-JiLee, Ju-YoungCho, Won-KyungKim, Jeong yeonWe, Young-ManMa, Jin YeulHoe, Hyang-Sook
Issue Date
Dec-2017
Publisher
SPANDIDOS PUBL LTD
Keywords
epimedium koreanum Nakai; cell migration; malignant human glioma cell; phorbol 12-myristate 13-acetate; NF-kappa B
Citation
ONCOLOGY REPORTS, v.38, no.6, pp.3619 - 3631
Journal Title
ONCOLOGY REPORTS
Volume
38
Number
6
Start Page
3619
End Page
3631
URI
http://scholarworks.bwise.kr/kbri/handle/2023.sw.kbri/763
DOI
10.3892/or.2017.6043
ISSN
1021-335X
Abstract
Previously, we showed that the herbal extract EYK (Epimedium koreanum Nakai) can regulate the immune response. Other studies showed that EYK has beneficial effects in human lung cancer, angiogenesis and Alzheimer's disease (AD). However, it remains unknown whether EYK can affect cancer cell migration and invasion in human brain cancer cell lines. In the present study, we found that pre-or post-treatment with EYK inhibited phorbol 12-myristate 13-acetate (PMA)-induced cancer cell migration and invasion in A172 cells, but not in U373MG or T98G cells. Additionally, pre-or post-treatment with PMA followed by EYK decreased MMP-9 activity in A172 cells. Moreover, treatment with a NF-kappa B inhibitor significantly decreased cell migration in A172 cells pre-or post-treated with EYK and PMA, suggesting that EYK requires NF-kappa B to alter cancer cell migration. Either pre-or post-treatment with EYK significantly decreased NF-kappa B nuclear translocation in comparison with PMA treatment. Taken together, our results suggest that EYK suppresses PMA-induced cancer cell migration in monomorphic malignant human glioma cells by downregulating the NF-kappa B pathway and decreasing MMP-9 activity.
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연구본부 > 퇴행성 뇌질환 연구그룹 > 1. Journal Articles
연구본부 > 정서·인지 질환 연구그룹 > 1. Journal Articles

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연구본부 (퇴행성뇌질환 연구그룹)
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