Early Pheromone Experience Modifies a Synaptic Activity to Influence Adult Pheromone Responses of C. elegans
- Authors
- Hong, Myeongjin; Ryu, Leesun; Ow, Maria C.; Kim, Jinmahn; Je, A. Reum; Chinta, Satya; Huh, Yang Hoon; Lee, Kea Joo; Butcher, Rebecca A.; Choi, Hongsoo; Sengupta, Piali; Hall, Sarah E.; Kim, Kyuhyung
- Issue Date
- Oct-2017
- Publisher
- CELL PRESS
- Citation
- CURRENT BIOLOGY, v.27, no.20, pp.3168 - +
- Journal Title
- CURRENT BIOLOGY
- Volume
- 27
- Number
- 20
- Start Page
- 3168
- End Page
- +
- URI
- http://scholarworks.bwise.kr/kbri/handle/2023.sw.kbri/767
- DOI
- 10.1016/j.cub.2017.08.068
- ISSN
- 0960-9822
- Abstract
- Experiences during early development can influence neuronal functions and modulate adult behaviors [1, 2]. However, the molecular mechanisms underlying the long-term behavioral effects of these early experiences are not fully understood. The C. elegans ascr#3 (asc-Delta C9; C9) pheromone triggers avoidance behavior in adult hermaphrodites [3-7]. Here, we show that hermaphrodites that are briefly exposed to ascr#3 immediately after birth exhibit increased ascr#3-specific avoidance as adults, indicating that ascr#3-experienced animals form a long-lasting memory or imprint of this early ascr# 3 exposure [8]. ascr#3 imprinting is mediated by increased synaptic activity between the ascr#3-sensing ADL neurons and their post-synaptic SMB motor neuron partners via increased expression of the odr-2 glycosylated phosphatidylinositol (GPI)-linked signaling gene in the SMB neurons. Our study suggests that the memory for early ascr#3 experience is imprinted via alteration of activity of a single synaptic connection, which in turn shapes experience-dependent plasticity in adult ascr#3 responses.
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