Polo-like kinase 2 phosphorylation of amyloid precursor protein regulates activity-dependent amyloidogenic processing
- Authors
- Lee, Yeunkum; Lee, Ji Soo; Lee, Kea Joo; Turner, R. Scott; Hoe, Hyang-Sook; Pak, Daniel T. S.
- Issue Date
- May-2017
- Publisher
- PERGAMON-ELSEVIER SCIENCE LTD
- Keywords
- Alzheimer' s disease; Amyloidogenic processing; Polo-like kinase 2; Synaptic plasticity; Neuronal signaling; Neurodegeneration; Hyperexcitation
- Citation
- NEUROPHARMACOLOGY, v.117, pp.387 - 400
- Journal Title
- NEUROPHARMACOLOGY
- Volume
- 117
- Start Page
- 387
- End Page
- 400
- URI
- http://scholarworks.bwise.kr/kbri/handle/2023.sw.kbri/825
- DOI
- 10.1016/j.neuropharm.2017.02.027
- ISSN
- 0028-3908
- Abstract
- Alzheimer's disease (AD) is a neurodegenerative disorder with cognitive deficits. Amyloidogenic processing of amyloid precursor protein (APP) produces amyloid beta (A beta), the major component of hallmark AD plaques. Synaptic activity stimulates APP cleavage, whereas APP promotes excitatory synaptic transmission, suggesting APP participates in neuronal homeostasis. However, mechanisms linking synaptic activity to APP processing are unclear. Here we show that Polo-like kinase 2 (Plk2), an activity-inducible regulator of homeostatic plasticity, directly binds and phosphorylates threonine-668 and serine-675 of APP in vitro and associates with APP in vivo. Plk2 accelerates APP amyloidogenic cleavage by P-secretase at synapses and is required for neuronal overactivity-stimulated A beta secretion. These findings implicate Plk2 as a novel mediator of activity-dependent APP amyloidogenic processing. (C) 2017 Elsevier Ltd. All rights reserved.
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Collections - 연구본부 > 퇴행성 뇌질환 연구그룹 > 1. Journal Articles
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