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Cited 24 time in webofscience Cited 26 time in scopus
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Neuroprotective Effects of Protein Tyrosine Phosphatase 1B Inhibition against ER Stress-Induced Toxicity

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dc.contributor.authorJeon, Yu-Mi-
dc.contributor.authorLee, Shinrye-
dc.contributor.authorKim, Seyeon-
dc.contributor.authorKwon, Younghwi-
dc.contributor.authorKim, Kiyoung-
dc.contributor.authorChung, Chang Geon-
dc.contributor.authorLee, Seongsoo-
dc.contributor.authorLee, Sung Bae-
dc.contributor.authorKim, Hyung-Jun-
dc.date.accessioned2023-08-16T09:51:21Z-
dc.date.available2023-08-16T09:51:21Z-
dc.date.created2022-01-13-
dc.date.issued2017-04-
dc.identifier.issn1016-8478-
dc.identifier.urihttp://scholarworks.bwise.kr/kbri/handle/2023.sw.kbri/827-
dc.description.abstractSeveral lines of evidence suggest that endoplasmic reticulum (ER) stress plays a critical role in the pathogenesis of many neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis. Protein tyrosine phosphatase 1B (PTP1B) is known to regulate the ER stress signaling pathway, but its role in neuronal systems in terms of ER stress remains largely unknown. Here, we showed that rotenone-induced toxicity in human neuroblastoma cell lines and mouse primary cortical neurons was ameliorated by PTP1B inhibition. Moreover, the increase in the level of ER stress markers (eIF2. phosphorylation and PERK phosphorylation) induced by rotenone treatment was obviously suppressed by concomitant PTP1B inhibition. However, the rotenone-induced production of reactive oxygen species (ROS) was not affected by PTP1B inhibition, suggesting that the neuroprotective effect of the PTP1B inhibitor is not associated with ROS production. Moreover, we found that MG132-induced toxicity involving proteasome inhibition was also ameliorated by PTP1B inhibition in a human neuroblastoma cell line and mouse primary cortical neurons. Consistently, downregulation of the PTP1B homologue gene in Dro-sophila mitigated rotenone-and MG132-induced toxicity. Taken together, these findings indicate that PTP1B inhibition may represent a novel therapeutic approach for ER stress-mediated neurodegenerative diseases.-
dc.language영어-
dc.language.isoen-
dc.publisherKOREAN SOC MOLECULAR & CELLULAR BIOLOGY-
dc.titleNeuroprotective Effects of Protein Tyrosine Phosphatase 1B Inhibition against ER Stress-Induced Toxicity-
dc.typeArticle-
dc.contributor.affiliatedAuthorJeon, Yu-Mi-
dc.contributor.affiliatedAuthorLee, Shinrye-
dc.contributor.affiliatedAuthorKim, Hyung-Jun-
dc.identifier.doi10.14348/molcells.2017.2320-
dc.identifier.scopusid2-s2.0-85018966490-
dc.identifier.wosid000403917300005-
dc.identifier.bibliographicCitationMOLECULES AND CELLS, v.40, no.4, pp.280 - 290-
dc.relation.isPartOfMOLECULES AND CELLS-
dc.citation.titleMOLECULES AND CELLS-
dc.citation.volume40-
dc.citation.number4-
dc.citation.startPage280-
dc.citation.endPage290-
dc.type.rimsART-
dc.type.docTypeArticle-
dc.identifier.kciidART002224260-
dc.description.journalClass1-
dc.description.isOpenAccessN-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.description.journalRegisteredClasskci-
dc.relation.journalResearchAreaBiochemistry & Molecular Biology-
dc.relation.journalResearchAreaCell Biology-
dc.relation.journalWebOfScienceCategoryBiochemistry & Molecular Biology-
dc.relation.journalWebOfScienceCategoryCell Biology-
dc.subject.keywordPlusENDOPLASMIC-RETICULUM STRESS-
dc.subject.keywordPlusSH-SY5Y NEUROBLASTOMA-CELLS-
dc.subject.keywordPlusNEUROTROPHIC FACTOR-
dc.subject.keywordPlusUP-REGULATION-
dc.subject.keywordPlusMETABOLIC DISEASE-
dc.subject.keywordPlusCORTICAL-NEURONS-
dc.subject.keywordPlusOXIDATIVE STRESS-
dc.subject.keywordPlusPROTEASOME-
dc.subject.keywordPlusDEATH-
dc.subject.keywordPlusPTP1B-
dc.subject.keywordAuthorendoplasmic reticulum stress (ER Stress)-
dc.subject.keywordAuthorMG132-
dc.subject.keywordAuthorreactive oxygen species (ROS)-
dc.subject.keywordAuthorrotenone-
dc.subject.keywordAuthorubiquitin proteasome system-
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