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Control of Adult Neurogenesis by Short-Range Morphogenic-Signaling Molecules

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dc.contributor.authorChoe Youngshik-
dc.contributor.authorPleasure Samuel J.-
dc.contributor.authorMira Helena-
dc.date.accessioned2023-08-16T09:51:25Z-
dc.date.available2023-08-16T09:51:25Z-
dc.date.created2022-06-03-
dc.date.issued2016-03-
dc.identifier.issn1943-0264-
dc.identifier.urihttp://scholarworks.bwise.kr/kbri/handle/2023.sw.kbri/858-
dc.description.abstractAdult neurogenesis is dynamically regulated by a tangled web of local signals emanating from the neural stem cell (NSC) microenvironment. Both soluble and membrane-bound niche factors have been identified as determinants of adult neurogenesis, including morphogens. Here, we review our current understanding of the role and mechanisms of short-range morphogen ligands from the Wnt, Notch, Sonic hedgehog, and bone morphogenetic protein (BMP) families in the regulation of adult neurogenesis. These morphogens are ideally suited to fine-tune stem-cell behavior, progenitor expansion, and differentiation, thereby influencing all stages of the neurogenesis process. We discuss cross talk between their signaling pathways and highlight findings of embryonic development that provide a relevant context for understanding neurogenesis in the adult brain. We also review emerging examples showing that the web of morphogens is in fact tightly linked to the regulation of neurogenesis by diverse physiologic processes.-
dc.publisherCOLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT-
dc.titleControl of Adult Neurogenesis by Short-Range Morphogenic-Signaling Molecules-
dc.typeArticle-
dc.contributor.affiliatedAuthorChoe Youngshik-
dc.identifier.wosid000371181600001-
dc.identifier.bibliographicCitationCOLD SPRING HARBOR PERSPECTIVES IN BIOLOGY, v.8, no.3-
dc.relation.isPartOfCOLD SPRING HARBOR PERSPECTIVES IN BIOLOGY-
dc.citation.titleCOLD SPRING HARBOR PERSPECTIVES IN BIOLOGY-
dc.citation.volume8-
dc.citation.number3-
dc.type.rimsART-
dc.description.journalClass1-
dc.description.isOpenAccessN-
dc.description.journalRegisteredClassscie-
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연구본부 (뇌발달질환 연구그룹)
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