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Cited 22 time in webofscience Cited 25 time in scopus
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SNX14 is a bifunctional negative regulator for neuronal 5-HT6 receptor signaling

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dc.contributor.authorHa, Chang Man-
dc.contributor.authorPark, Daehun-
dc.contributor.authorKim, Yoonju-
dc.contributor.authorNa, Myeongsu-
dc.contributor.authorPanda, Surabhi-
dc.contributor.authorWon, Sehoon-
dc.contributor.authorKim, Hyun-
dc.contributor.authorRyu, Hoon-
dc.contributor.authorPark, Zee Yong-
dc.contributor.authorRasenick, Mark M.-
dc.contributor.authorChang, Sunghoe-
dc.date.accessioned2023-08-16T09:51:28Z-
dc.date.available2023-08-16T09:51:28Z-
dc.date.created2022-01-11-
dc.date.issued2015-05-
dc.identifier.issn0021-9533-
dc.identifier.urihttp://scholarworks.bwise.kr/kbri/handle/2023.sw.kbri/878-
dc.description.abstractThe 5-hydroxytryptamine (5-HT, also known as serotonin) subtype 6 receptor (5-HT6R, also known as HTR6) plays roles in cognition, anxiety and learning and memory disorders, yet new details concerning its regulation remain poorly understood. In this study, we found that 5-HT6R directly interacted with SNX14 and that this interaction dramatically increased internalization and degradation of 5-HT6R. Knockdown of endogenous SNX14 had the opposite effect. SNX14 is highly expressed in the brain and contains a putative regulator of G-protein signaling (RGS) domain. Although its RGS domain was found to be non-functional as a GTPase activator for Gas, we found that it specifically bound to and sequestered Gas, thus inhibiting downstream cAMP production. We further found that protein kinase A (PKA)-mediated phosphorylation of SNX14 inhibited its binding to Gas and diverted SNX14 from Gas binding to 5-HT6R binding, thus facilitating the endocytic degradation of the receptor. Therefore, our results suggest that SNX14 is a dual endogenous negative regulator in 5-HT6R-mediated signaling pathway, modulating both signaling and trafficking of 5-HT6R.-
dc.language영어-
dc.language.isoen-
dc.publisherCOMPANY OF BIOLOGISTS LTD-
dc.titleSNX14 is a bifunctional negative regulator for neuronal 5-HT6 receptor signaling-
dc.typeArticle-
dc.contributor.affiliatedAuthorHa, Chang Man-
dc.identifier.doi10.1242/jcs.169581-
dc.identifier.scopusid2-s2.0-84929494363-
dc.identifier.wosid000354873100018-
dc.identifier.bibliographicCitationJOURNAL OF CELL SCIENCE, v.128, no.9, pp.1848 - 1861-
dc.relation.isPartOfJOURNAL OF CELL SCIENCE-
dc.citation.titleJOURNAL OF CELL SCIENCE-
dc.citation.volume128-
dc.citation.number9-
dc.citation.startPage1848-
dc.citation.endPage1861-
dc.type.rimsART-
dc.type.docTypeArticle-
dc.description.journalClass1-
dc.description.isOpenAccessN-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.relation.journalResearchAreaCell Biology-
dc.relation.journalWebOfScienceCategoryCell Biology-
dc.subject.keywordPlusSEROTONIN RECEPTORS-
dc.subject.keywordPlusSORTING NEXINS-
dc.subject.keywordPlusPROTEIN-
dc.subject.keywordPlusBRAIN-
dc.subject.keywordPlusPHOSPHORYLATION-
dc.subject.keywordPlusLOCALIZATION-
dc.subject.keywordPlusDRUGS-
dc.subject.keywordPlusSCHIZOPHRENIA-
dc.subject.keywordPlusSTIMULATION-
dc.subject.keywordPlusTRAFFICKING-
dc.subject.keywordAuthorSNX14-
dc.subject.keywordAuthorG protein-coupled receptor-
dc.subject.keywordAuthorRegulator of G protein signaling-
dc.subject.keywordAuthorSorting nexin-
dc.subject.keywordAuthorGuanosine triphosphatase-activating proteins-
dc.subject.keywordAuthor5-hydroxytryptamine type 6 receptor-
dc.subject.keywordAuthor5-HT-
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